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Clinical Trials/NCT06747793
NCT06747793
Not yet recruiting
Not Applicable

Evaluation of the Use of Virtual Reality to Reduce Anxiety in Intensive Care Patients

University Hospital, Toulouse1 site in 1 country128 target enrollmentFebruary 2025

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Anxiety
Sponsor
University Hospital, Toulouse
Enrollment
128
Locations
1
Primary Endpoint
Patients' anxiety level after using virtual reality
Status
Not yet recruiting
Last Updated
last year

Overview

Brief Summary

Anxiety and discomfort generated by repeated medical cares and invasive procedures can induce cognitive disorders in critical illness survivors as post-traumatic stress disorder. For this reason, managing patients' anxiety is particularly important in the intensive care unit. Physicians have recently started using immersive virtual reality (VR), based on real-time interaction with an artificial 360° immersive world, as an adjunctive non-invasive and non-pharmacological anxiolysis technique. The purpose of this project is to assess the virtual reality stimulation to reduce anxiety in Intensive Care Unit (ICU) patients.

Detailed Description

Physicians have recently started using immersive VR as an adjunctive non-invasive and non-pharmacological pain control and anxiolysis technique, but the literature on this topic in the adult ICU is quite sparse. In a pilot study, Gerber et al showed the feasibility and acceptance of VR stimulation as a new non-pharmacological intervention to comfort patients during their stay in the ICU and the results appear promising \[11\]. In our view, the management of anxiety related to healthcare interventions remains a major global challenge and it will be interesting to assess the use of VR in a chronic daily use in the ICU adult patients. Our study will be conducted in the adult intensive care unit of the University of Toulouse, France. All patients who meet the inclusion criteria will be randomized. There will be two distinct groups: the control group will receive standard ICU care, whereas the intervention group will, in addition to the standard ICU care, will receive relaxing VR stimulation two times a day. The intervention will be performed by trained ICU nurses. Anxiety will be assessed by the Visual Analogue Scale for Anxiety (VAS-A) twice by day (morning and evening), sleep quality with the Richards-Campbell Sleep Questionnaire (RCSQ) every morning, depression, and anxiety with the Hamilton Depression Rating Scale (HDRS) and the Hamilton Anxiety Rating Scale (HAM-A) at 3-months after the inclusion. Each patient's heart rate, blood pressure, respiration rate, SatO2, and physical or neurocognitive side effects were used to evaluate if the VR sessions will have any effect on physiology.

Registry
clinicaltrials.gov
Start Date
February 2025
End Date
January 2027
Last Updated
last year
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Adult patient
  • Oral consent after free and informed information
  • Hospitalized in the multipurpose intensive care unit of Rangueil hospital with an estimated length of stay greater than 24 hours
  • Conscious (Glasgow Coma Scale \> 8) and Richmond Agitation-Sedation Scale (RASS) sedation score between -1 and +1
  • Mechanically ventilated or not
  • Person affiliated to or beneficiary of a social security system.

Exclusion Criteria

  • Patient under legal protection (guardianship or curatorship)
  • RASS \< -1 or \> +1
  • Visual or hearing difficulties preventing the use of the VR headset
  • Severe psychiatric history (severe depression, psychosis, bipolarity), advanced dementia or mental retardation
  • Hemodynamic (Norepinephrine support \> 0.5 gamma/kg/min) and/or respiratory instability (invasive mechanical ventilation with FiO2 greater than 80%)
  • Presence of a malformation or cervical or facial trauma that does not allow the application of the VR headset
  • Pregnancy or breastfeeding

Outcomes

Primary Outcomes

Patients' anxiety level after using virtual reality

Time Frame: 7 days

Visual Analogue Scale for Anxiety (VAS-A) is a scale measuring anxiety from 0 to 100 ; 0: no anxiety, 100: maximum of anxiety

Secondary Outcomes

  • Difference in patient anxiety after using virtual reality(between inclusion and the day 7)
  • Evolution of the psychopathological status: depression(3 months)
  • Evolution of the psychopathological status: anxiety(3 months)
  • Evolution of the Sleep quality(every day through study completion, an average of 5 days)
  • Evaluation of the Safety of using vitural reality in intensive care unit(every day through study completion, an average of 5 days)
  • Evaluation of the compliance(3 months)

Study Sites (1)

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