Effect of walnut (juglans regia L.) consumption on biomarkers of inflammation and oxidative stress in middle-aged and elderly people: a randomized controlled trial

University of Medicine and Pharmacy Iuliu Ha?ieganu Cluj-Napoca0 个研究点目标入组 22 人开始时间: 2024年9月26日最近更新: 2024年9月30日

适应症

试验速览

阶段: Unknown
状态: 已完成
发起方
入组人数: 22
主要终点: Assessment of blood vascular cell adhesion molecule (s-VCAM) levels using Elisa Kit at baseline and at the end of each intervention period.

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•Caucasian adults, women and men aged 40-65 years
•With no known allergy to walnuts
•Provide informed consent
•Clinical characteristics: healthy individuals at MetS risk with at least one of the specific parameters present, including: 4.
•Abdominal obesity: waist circumference (WC) = 102 cm and = 88 cm for European men and women, respectively4.
•Hypertension: systolic blood pressure (SBP) = 130 mmHg or/and diastolic blood pressure (DBP) = 85 mmHg4.
•Dyslipidemia: TG = 150 mg/dL and high-density lipoprotein cholesterol (HDL-c) < 40 mg/dL in men or < 50 mg/dL in women4.
•Dysglycemia: fasting blood glucose (FBG) = 100 mg/dL

•Individuals with allergies to walnuts, other tree nuts, and peanuts or following restric-tive diets for food allergies, food intolerances (lactose, fructose, gluten)
•Diets for chronic gastrointestinal or kidney disease, vegetarians, or other types of diet that could interfere with study results, as well as those with current or recent eating disorders (last 6 months prior to the start of the study).
•Individuals with current chronic diseases: chronic intestinal diseases (ulcerative colitis, Crohn's disease), chronic renal disease, CVD, pulmonary disease, Type 1 or 2 diabetes, cancer, neurodegenerative diseases (Alzheimer's disease, Parkinson's disease), gallbladder disorders (gallbladder lithiasis, biliary dyskinesia, and acute or chronic cholecystitis)
•Drug treatments (insulin therapy, hypoglycemic and/or hypolipidemic treatments, chronic treatment with non-steroidal and/or steroidal an-ti-inflammatory drugs)
•Concomitant use or at least two weeks prior to the start of the study of dietary supplements (vitamins or minerals, anti-inflammatory and/or antiox-idant compounds, including fish oil, omega-3 fatty acids, resveratrol, curcumin, vita-min C, selenium, zinc, as well as dietary fiber, probiotics, symbiotics).
•Chronic alcohol consumption

Assessment of blood vascular cell adhesion molecule (s-VCAM) levels using Elisa Kit at baseline and at the end of each intervention period.

未报告次要终点

发起方

University of Medicine and Pharmacy Iuliu Ha?ieganu Cluj-Napoca