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Clinical Trials/NCT03602040
NCT03602040
Suspended
Not Applicable

A Psychoeducational Intervention Supporting Patients With a New Diagnosis and/or Genetic Carrier Status for an Inherited Cardiac Condition-a Feasibility Study

King's College London1 site in 1 country24 target enrollmentJune 2022

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Inherited Cardiac Conduction Disorder
Sponsor
King's College London
Enrollment
24
Locations
1
Primary Endpoint
Engagement of clinical staff with identification of patients
Status
Suspended
Last Updated
5 years ago

Overview

Brief Summary

Inherited heart conditions (IHCs) can cause young sudden deaths due to a genetic trait that leads to a thickened heart muscle or abnormal heart rhythms. Relatives of an affected person have a 50% chance of inheriting IHCs and this is determined either through a blood test (predictive genetic test) and/or physical tests such as a heart tracing (electrocardiogram), scan (echocardiogram) and exercise test. When patients find out they are affected or are carriers for an IHC, they have numerous questions about medical management, prognosis, lifestyle; as well as experiencing stress and anxiety because of the impact on their health and risk to their family. Based on published studies and interviews, a psychoeducational intervention underpinned by Self-determination Theory was developed to support these patients An uncontrolled study to determine the feasibility of the intervention and outcome measures will be undertaken. Patients with a new IHC diagnosis or a carrier result aged 16 years and older will be recruited from outpatient clinics in London and will be receive the intervention consisting of a disease-specific information leaflet, a personalised lifestyle consideration guide and participation in a 1-hour group session facilitated by a cardiac genetic nurse. Outcome measures to look at degree of self-determination, autonomy support and competence; and heart-related anxiety will be collected at baseline and at 3 months post intervention. Clinical and socio-demographic data will be obtained from medical notes. The feasibility and acceptability of the intervention will be measured by assessment of the study procedures such as recruitment, retention and any adverse events. It is expected that there will be up to 4 consecutive group sessions and feedback from each session will be used to co-design and refine the intervention model for a definitive clinical trial.

Registry
clinicaltrials.gov
Start Date
June 2022
End Date
June 2024
Last Updated
5 years ago
Study Type
Interventional
Study Design
Single Group
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Patients who are aged 16 and older.
  • Patients who have undergone cardiac screening and/or predictive genetic testing for inherited cardiac conditions and are within 6 months of receiving a new diagnosis of an inherited cardiac condition (ICC) and/or have been found to be carriers of a genetic alteration that can cause an ICC.

Exclusion Criteria

  • Patients who were initially referred to the clinic for reasons other than cardiac screening and/or predictive genetic testing for ICCs.
  • Patients who have undergone cardiac screening and/or predictive genetic testing for ICCs and more than 6 months have passed since receiving a new diagnosis of an ICC and/or a carrier result for a genetic alteration that can cause an ICC.
  • Patients who have undergone cardiac screening and/or predictive genetic testing for ICCs and have received a negative result.
  • Patients below 16 years of age.
  • Patients with insufficient command of written and spoken English to comprehend study documents and participate in the study procedures and discussion.
  • Patients who are already participating in a study involving a psychoeducational intervention, novel cardiac medication or device.

Outcomes

Primary Outcomes

Engagement of clinical staff with identification of patients

Time Frame: 3 months

Number of participants identified for recruitment

Engagement of participants with recruitment procedures

Time Frame: 3 months

Number of participants consented, number of participants declined and withdrawn

Completion of data collection

Time Frame: 3 months

Rates of data collection at baseline and follow-up, and reasons for missing data

Engagement with psychoeducational intervention

Time Frame: 3 months

Rates of intervention uptake and reasons for dropout

Secondary Outcomes

  • Perceived Competence Scale(Measured at baseline and 3 months post intervention)
  • Perceived Choice and Awareness of Self Scale(Measured at baseline and 3 months post intervention)
  • Health Care Climate Questionnaire(Measured at baseline and 3 months post intervention)
  • Heart-related Anxiety (Questionnaire)(Measured at baseline and 3 months post intervention)

Study Sites (1)

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