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Clinical Trials/NCT05129631
NCT05129631
Completed
Not Applicable

HEARTPrep: A Virtually-delivered Psychosocial Intervention for Mothers Expecting a Baby With Congenital Heart Disease

Nemours Children's Clinic1 site in 1 country30 target enrollmentJuly 14, 2023

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Congenital Heart Disease
Sponsor
Nemours Children's Clinic
Enrollment
30
Locations
1
Primary Endpoint
HEARTPrep Evaluation Questionnaire
Status
Completed
Last Updated
10 months ago

Overview

Brief Summary

Congenital heart disease (CHD) is the most common birth defect and is increasingly diagnosed prenatally. Mothers describe their prenatal experiences as highly stressful and traumatic after a diagnosis of CHD. Maternal stress during pregnancy exerts a powerful influence on birth outcomes and developmental trajectories, particularly for children in underserved populations. In partnership with diverse parent and clinician stakeholders, our team designed HEARTPrep, an innovative, virtually-delivered psychosocial intervention for mothers expecting a baby with CHD. This project will pilot HEARTPrep with mothers expecting a baby with CHD to obtain preliminary data for a larger future trial. This intervention has the potential to improve emotional wellbeing in mothers expecting a baby with CHD, thereby altering developmental trajectories for this large population of children.

Detailed Description

Congenital heart disease (CHD) is the most common birth defect and is increasingly diagnosed prenatally. Mothers describe their prenatal experiences as highly stressful and traumatic after a diagnosis of CHD. Maternal stress during pregnancy exerts a powerful influence on birth outcomes and developmental trajectories, particularly for children in underserved populations. Targeted efforts to mitigate impacts of maternal stress for this highly vulnerable population are lacking. In partnership with diverse parent and clinician stakeholders, the investigators designed HEARTPrep, an innovative, virtually-delivered psychosocial intervention for mothers expecting a baby with CHD. HEARTPrep will be delivered through the Nemours App, an accessible tool for telehealth and patient education. The investigators aim to determine whether HEARTPrep modules produce clinically significant improvements on outcomes in mothers expecting a baby with CHD (Proof-of-Concept). This program of research has the potential to improve emotional wellbeing in mothers expecting a baby with CHD, thereby altering developmental trajectories for this large population of children.

Registry
clinicaltrials.gov
Start Date
July 14, 2023
End Date
May 31, 2025
Last Updated
10 months ago
Study Type
Interventional
Study Design
Single Group
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Erica Sood

Pediatric Psychologist

Nemours Children's Clinic

Eligibility Criteria

Inclusion Criteria

  • Expectant mothers carrying a fetus with congenital heart disease expected to require cardiac surgery in the first year of life
  • Partners of participating expectant mothers can also participate together with the mother
  • Receiving fetal cardiac care at Nemours Children's Health
  • Speaks English or Spanish fluently
  • Age 18 or older
  • Access to a computer, tablet or mobile device with internet access

Exclusion Criteria

  • Fetus has a genetic syndrome or other comorbid condition associated with a life expectancy of less than one year

Outcomes

Primary Outcomes

HEARTPrep Evaluation Questionnaire

Time Frame: Post-intervention

Assesses perceived acceptability and feasibility of HEARTPrep (item responses range from 0-4 with higher scores reflecting greater acceptability and feasibility; minimum score = 0; maximum score = 64)

Change in Emotional Distress - Patient-Reported Outcomes Measurement Information System (PROMIS) Short-Form

Time Frame: Weeks 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12

Assesses change from baseline in feelings of anxiety and depression (item responses range from 1-5 with higher scores reflecting greater emotional distress; minimum score = 4; maximum score = 20)

Change in Social Isolation - PROMIS Short-Form

Time Frame: Weeks 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12

Assesses change from baseline in feelings of social isolation (item responses range from 1-5 with higher scores reflecting greater social isolation; minimum score = 4; maximum score = 20)

Change in Parenting Self-Efficacy - PROMIS Short-Form

Time Frame: Weeks 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12

Assesses change from baseline in feelings of parenting self-efficacy (item responses range from 1-5 with lower scores reflecting lower parenting self-efficacy; minimum score = 4; maximum score = 20)

Secondary Outcomes

  • Change in Hope - PROMIS Short-Form(Weeks 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)

Study Sites (1)

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