Investigating the effect of ondansetron on Levodopa-induced dyskinesia in patients with parkinson's disease

Phase 3

Recruiting

• Conditions: levodopa-induced dyskinesia.; Neuroleptic induced parkinsonism; G21.11

• Registration Number: IRCT20190427043389N5
• Lead Sponsor: Zanjan University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 January 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 32

Inclusion Criteria

patients with Parkinson's disease stages 3, and 4 based on Hoehn and Yahr scale
age over 18 years
patients with levodpa induced dyskinesia
Patient satisfaction

Exclusion Criteria

Allergy to ondansetron (rash, itching)
Concomitant use of apomorphine in patients with off episodes
pregnancy
breastfeeding
The patient's unwillingness for participation

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
evodopa induced dyskinesia score in Unified Dyskinesia Rating Scale questionnare. Timepoint: Before intervention, one and two months after starting intervention. Method of measurement: Unified Dyskinesia Rating Scale questionnare.

Secondary Outcome Measures

Name	Time	Method
evodopa-induced dyskinesia 's severity. Timepoint: Before starting intervention, one and two months after starting intervention. Method of measurement: Unified Dyskinesia Rating Scale questionnare.