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临床试验/NCT04154540
NCT04154540已完成不适用

Study of Gait and Posture in Subacute Acquired Neuropathies and in Hereditary Neuropathies

University Hospital, Lille1 个研究点 分布在 1 个国家目标入组 67 人开始时间: 2021年5月19日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
67
试验地点
1
主要终点
Posturography (Romberg's quotient)

研究概览

简要总结

If the classification between hereditary and acquired neuropathy is often easy, there is no completely specific marker allowing the distinction between the two etiologies. Clinical experience suggests that hereditary neuropathies have less impact on balance and gait than the acquired neuropathies at equivalent level of impairment, but this has never been clearly demonstrated.

研究设计

研究类型
Interventional
分配方式
Non Randomized
干预模型
Parallel
主要目的
Other
盲法
None

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者
否

入选标准

  • •CMT1A for molecular-proven Group 1 (PMP22 duplication)
  • •IPDC likely or defined for Group 2
  • •Able to walk 10 m unassisted

排除标准

  • •Neurological history other than neuropathy: epilepsy, stroke, dementia
  • •Pregnant women
  • •Person under guardianship or trusteeship
  • •Musculoskeletal conditions other than neuropathy impairing walking abilities
  • •Major comorbidity considered a contraindication by the investigator (cancer, unstable angor, etc.)

研究组 & 干预措施

demyelinating hereditary neuropathy

Experimental

adult patients with demyelinating hereditary neuropathy type CMT 1A.

干预措施: Motion analysis (Other)

demyelinating inflammatory neuropathy

Experimental

adult patients with acquired demyelinating inflammatory neuropathy.

干预措施: Motion analysis (Other)

结局指标

主要结局

Posturography (Romberg's quotient)

时间窗: Time 0 ; single session

次要结局

  • stride time (in seconde) parameters(Time 0 ; single session)
  • velocity (meter/seconde) parameters(Time 0 ; single session)
  • cadence (step/min) parameters(Time 0 ; single session)
  • The Timed Up and Go test (TUG)(Time 0 ; single session)
  • stride length (in millimeters) parameters(Time 0 ; single session)

研究者

发起方
University Hospital, Lille
申办方类型
Other
责任方
Sponsor

研究点 (1)

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