NCT04131244已完成不适用
In Vitro Follicle Activation of Dormant Follicles in Patient With Premature Ovarian Failure Under 36 Years Old
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- Live birth
研究概览
简要总结
This is a clinical trial that the investigators aim to validate In-vitro Activation (IVA) treatment protocol, which was previously defined by Kazuhiro Kawamura (MD) and Aaron Hsueh (PhD), in Turkish patient with Premature Ovarian Insufficiency (POI) under age 36.
详细描述
The objectives of the study is as following;
- Validation of the previously defined In-Vitro Activation Protocol approach in Turkish patients under 36 years old with Premature Ovarian Insufficiency (POI).
- Giving an opportunity to young POI patient in Turkey for having genetically own baby.
- Primary outcome measure would be live birth.
- For activation of primordial follicles, phosphatase and tensin homolog (PTEN) inhibitor and protein kinase B (AKT) stimulator will be used.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 36 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Patient with POI
- •Short amenorrhea period (1 - 2 years)
排除标准
- •Having been treated with chemotherapy and/or radiotherapy;
- •Having been diagnosed with advanced stage of endometriosis (endometriomas)
- •Having been diagnosed with the chronic diseases such as diabetes, cardiac failure, kidney insufficiency, morbid obesity etc..
- •Presence of chromosomal abnormality (Turner, Fragile-X etc.)
- •Previous multiple laparotomies
- •Menopause >10 years
- •Accompanied azoospermia
结局指标
主要结局
Live birth
时间窗: 2 years
The primary outcome is live birth, defined as the delivery of a live-born infant at 24 weeks of gestation
次要结局
- Follicle growth rate(1 year)
- M-II oocyte rate(1 year)
- Day 2-3 good quality embryo rate(1 year)
- Clinical pregnancy rate(2 years)
研究者
Sezcan Mumusoglu
Assistant Professor
Hacettepe University
研究点 (2)
Loading locations...
相似试验
终止
不适用
In Vitro Follicle ActivationPrimary Ovarian InsufficiencyInfertilityNCT02496598National Foundation for Fertility Research2
暂停
不适用
In Vitro Maturation With in Vitro Fertilization (IVF) Compared to Mild in Vitro FertilizationInfertilityNCT00867763Batzofin Fertility Services1,440
终止
不适用
An In-vitro Standardization of B Cell Elispot AssaysTransplant SensitizationPanel Reactive AntibodySensitization to HLA AntigensNCT01334281Northwestern University19
Unknown
早期 1 期
Natural Killer Cells Infusion for Treating Acute Myeloid Leukemia Patients With Minimal Residual DiseaseAcute Myeloid LeukemiaNCT04209712Shanghai iCELL Biotechnology Co., Ltd, Shanghai, China6
进行中（未招募）
不适用
In Vitro Maturation (IVM) as part of the treatment of infertility in women with polycystic ovaries (PCO).Is priming with hCG favourable? A prospective randomized study.Infertility in women with polycystic ovaries (PCO).EUCTR2006-000194-29-DKFertility Clinic, dept. of Obstetrics and gynecology, OUH.200