Relative Bioavailability Trial of Dapivirine Ring-004 and Ring-008
- First Posted Date
- 2022-06-13
- Last Posted Date
- 2024-07-03
- Lead Sponsor
- International Partnership for Microbicides, Inc.
- Target Recruit Count
- 124
- Registration Number
- NCT05416021
- Locations
- πΏπ¦
FARMOVS, Bloemfontein, South Africa
PK, Safety Study of 90-Day Use of Vaginal Rings Containing Dapivirine and Levonorgestrel
Phase 1
Completed
- Conditions
- BleedingSafety IssuesPharmacokinetics
- Interventions
- Combination Product: IPM Ring-105Combination Product: IPM Ring-106
- First Posted Date
- 2021-09-13
- Last Posted Date
- 2024-11-05
- Lead Sponsor
- International Partnership for Microbicides, Inc.
- Target Recruit Count
- 40
- Registration Number
- NCT05041699
- Locations
- πΊπΈ
Oregon Health & Science University, Portland, Oregon, United States
πΊπΈUPMC Magee-Womens Hospital, Center for Family Planning Research, Pittsburgh, Pennsylvania, United States
PK Study of 90-Day Use of Vaginal Rings Containing Dapivirine and Levonorgestrel
Phase 1
Completed
- Conditions
- ContraceptionWomenHealthyContraceptive Usage
- First Posted Date
- 2018-03-16
- Last Posted Date
- 2019-10-09
- Lead Sponsor
- International Partnership for Microbicides, Inc.
- Target Recruit Count
- 25
- Registration Number
- NCT03467347
- Locations
- πΊπΈ
Magee-Women'S Res Inst and Foundation, Pittsburgh, Pennsylvania, United States
A Phase 1, Randomized Pharmacokinetics and Safety Study of Extended Duration Dapivirine Vaginal Rings
Phase 1
Completed
- Conditions
- HIV-1-infection
- Interventions
- Combination Product: Dapivirine Vaginal Ring, 25 mgCombination Product: Dapivirine Vaginal Ring, 200 mgCombination Product: Dapivirine Vaginal Ring, 100 mg
- First Posted Date
- 2017-07-31
- Last Posted Date
- 2019-01-29
- Lead Sponsor
- International Partnership for Microbicides, Inc.
- Target Recruit Count
- 49
- Registration Number
- NCT03234400
- Locations
- πΊπΈ
University of Alabama at Birmingham, Birmingham, Alabama, United States
πΊπΈBridge HIV CRS San Francisco Department of Public Health, San Francisco, California, United States
Reversing the Epidemic in Africa With Choices in HIV Prevention (REACH)
- First Posted Date
- 2017-03-09
- Last Posted Date
- 2017-09-08
- Lead Sponsor
- International Partnership for Microbicides, Inc.
- Registration Number
- NCT03074786
- Locations
- πΏπ¦
CAPRISA, eThekwini Clinical Research Site, Durban, KwaZulu-Natal, South Africa
Dapivirine Gel Rectal Safety and PK Study
Phase 1
Withdrawn
- Conditions
- HIV 1 Infection
- Interventions
- Other: Universal HEC placebo gel
- First Posted Date
- 2017-02-07
- Last Posted Date
- 2017-02-08
- Lead Sponsor
- International Partnership for Microbicides, Inc.
- Registration Number
- NCT03044379
- Locations
- πΊπΈ
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
Safety and Pharmacokinetic Trial in Healthy HIV-Negative Women to Assess the Delivery of Dapivirine From a Vaginal Ring
Phase 1
Completed
- Conditions
- HIV Infections
- Interventions
- Combination Product: Placebo vaginal ringCombination Product: Dapivirine Vaginal Ring
- First Posted Date
- 2016-09-30
- Last Posted Date
- 2017-09-08
- Lead Sponsor
- International Partnership for Microbicides, Inc.
- Target Recruit Count
- 16
- Registration Number
- NCT02920827
- Locations
- π§πͺ
SGS Life Sciences Center, Antwerp, Flanders, Belgium
Evaluate the Safety & Assess Local and Systemic PK of DS003 Vaginal Tablets Administered to Healthy HIV-negative Women
Phase 1
Completed
- Conditions
- HIV
- Interventions
- Drug: DS003 vaginal tabletDrug: Placebo
- First Posted Date
- 2016-08-25
- Last Posted Date
- 2017-08-24
- Lead Sponsor
- International Partnership for Microbicides, Inc.
- Target Recruit Count
- 36
- Registration Number
- NCT02877979
To Assess Continued Safety of and Adherence to the Dapivirine (25 mg) Vaginal Ring-004 in Healthy, HIV-negative Women
- First Posted Date
- 2016-08-10
- Last Posted Date
- 2022-10-25
- Lead Sponsor
- International Partnership for Microbicides, Inc.
- Target Recruit Count
- 941
- Registration Number
- NCT02862171
- Locations
- πΏπ¦
Qhakaza Mbokodo, Ladysmith, KZN, South Africa
πΏπ¦MatCH Research Unit, Pietermaritzburg, KZN, South Africa
πΏπ¦Madibeng Centre for Research, Brits, North West, South Africa
A Trial In Healthy HIV-Negative Women To Assess The Effect Of Menses And Tampon Use On The Pharmacokinetics Of Dapivirine, Delivered By Dapivirine Vaginal Ring-004, Containing 25 Mg Of Dapivirine
Phase 1
Completed
- Conditions
- HIV
- Interventions
- First Posted Date
- 2016-08-08
- Last Posted Date
- 2017-09-06
- Lead Sponsor
- International Partnership for Microbicides, Inc.
- Target Recruit Count
- 16
- Registration Number
- NCT02858024