Relative Bioavailability Trial of Dapivirine Ring-004 and Ring-008
- First Posted Date
- 2022-06-13
- Last Posted Date
- 2024-07-03
- Lead Sponsor
- International Partnership for Microbicides, Inc.
- Target Recruit Count
- 124
- Registration Number
- NCT05416021
- Locations
- 🇿🇦
FARMOVS, Bloemfontein, South Africa
PK, Safety Study of 90-Day Use of Vaginal Rings Containing Dapivirine and Levonorgestrel
- Conditions
- BleedingSafety IssuesPharmacokinetics
- Interventions
- Combination Product: IPM Ring-105Combination Product: IPM Ring-106
- First Posted Date
- 2021-09-13
- Last Posted Date
- 2024-11-05
- Lead Sponsor
- International Partnership for Microbicides, Inc.
- Target Recruit Count
- 40
- Registration Number
- NCT05041699
- Locations
- 🇺🇸
UPMC Magee-Womens Hospital, Center for Family Planning Research, Pittsburgh, Pennsylvania, United States
🇺🇸Oregon Health & Science University, Portland, Oregon, United States
PK Study of 90-Day Use of Vaginal Rings Containing Dapivirine and Levonorgestrel
- Conditions
- ContraceptionWomenHealthyContraceptive Usage
- First Posted Date
- 2018-03-16
- Last Posted Date
- 2019-10-09
- Lead Sponsor
- International Partnership for Microbicides, Inc.
- Target Recruit Count
- 25
- Registration Number
- NCT03467347
- Locations
- 🇺🇸
Magee-Women'S Res Inst and Foundation, Pittsburgh, Pennsylvania, United States
A Phase 1, Randomized Pharmacokinetics and Safety Study of Extended Duration Dapivirine Vaginal Rings
- Conditions
- HIV-1-infection
- Interventions
- Combination Product: Dapivirine Vaginal Ring, 25 mgCombination Product: Dapivirine Vaginal Ring, 200 mgCombination Product: Dapivirine Vaginal Ring, 100 mg
- First Posted Date
- 2017-07-31
- Last Posted Date
- 2019-01-29
- Lead Sponsor
- International Partnership for Microbicides, Inc.
- Target Recruit Count
- 49
- Registration Number
- NCT03234400
- Locations
- 🇺🇸
Bridge HIV CRS San Francisco Department of Public Health, San Francisco, California, United States
🇺🇸University of Alabama at Birmingham, Birmingham, Alabama, United States
Reversing the Epidemic in Africa With Choices in HIV Prevention (REACH)
- First Posted Date
- 2017-03-09
- Last Posted Date
- 2017-09-08
- Lead Sponsor
- International Partnership for Microbicides, Inc.
- Registration Number
- NCT03074786
- Locations
- 🇿🇦
CAPRISA, eThekwini Clinical Research Site, Durban, KwaZulu-Natal, South Africa
Dapivirine Gel Rectal Safety and PK Study
- Conditions
- HIV 1 Infection
- Interventions
- Other: Universal HEC placebo gel
- First Posted Date
- 2017-02-07
- Last Posted Date
- 2017-02-08
- Lead Sponsor
- International Partnership for Microbicides, Inc.
- Registration Number
- NCT03044379
- Locations
- 🇺🇸
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
Safety and Pharmacokinetic Trial in Healthy HIV-Negative Women to Assess the Delivery of Dapivirine From a Vaginal Ring
- Conditions
- HIV Infections
- Interventions
- Combination Product: Placebo vaginal ringCombination Product: Dapivirine Vaginal Ring
- First Posted Date
- 2016-09-30
- Last Posted Date
- 2017-09-08
- Lead Sponsor
- International Partnership for Microbicides, Inc.
- Target Recruit Count
- 16
- Registration Number
- NCT02920827
- Locations
- 🇧🇪
SGS Life Sciences Center, Antwerp, Flanders, Belgium
Evaluate the Safety & Assess Local and Systemic PK of DS003 Vaginal Tablets Administered to Healthy HIV-negative Women
- Conditions
- HIV
- Interventions
- Drug: DS003 vaginal tabletDrug: Placebo
- First Posted Date
- 2016-08-25
- Last Posted Date
- 2017-08-24
- Lead Sponsor
- International Partnership for Microbicides, Inc.
- Target Recruit Count
- 36
- Registration Number
- NCT02877979
To Assess Continued Safety of and Adherence to the Dapivirine (25 mg) Vaginal Ring-004 in Healthy, HIV-negative Women
- First Posted Date
- 2016-08-10
- Last Posted Date
- 2022-10-25
- Lead Sponsor
- International Partnership for Microbicides, Inc.
- Target Recruit Count
- 941
- Registration Number
- NCT02862171
- Locations
- 🇿🇦
Madibeng Centre for Research, Brits, North West, South Africa
🇿🇦Ndlovu Medical Centre, Elandsdoorn, South Africa
🇺🇬MRC/UVRI Uganda Research Unit on AIDS, Entebbe, Uganda
Trial to Assess the Continued Safety of and Adherence to a Vaginal Ring Containing Dapivirine in Women
- Conditions
- Human Immunodeficiency Virus
- Interventions
- Combination Product: Dapivirine Vaginal Ring
- First Posted Date
- 2016-08-08
- Last Posted Date
- 2022-10-25
- Lead Sponsor
- International Partnership for Microbicides, Inc.
- Target Recruit Count
- 1456
- Registration Number
- NCT02858037
- Locations
- 🇿🇦
Emavundleni Research Centre, Cape Town, Western Cape, South Africa
🇲🇼Malawi Clinical Research Center, Lilongwe, Malawi
🇺🇬Makerere University - Johns Hopkins University Research Collaboration Clinical Research Center, Kampala, Uganda