Comparison of Circumferential Pulmonary Vein Isolation Alone Versus Linear Ablation in Addition to Circumferential Pulmonary Vein Isolation for Catheter Ablation in Persistent Atrial Fibrillation: Prospective Randomized Controlled Trial

Not Applicable

• Conditions: Atrial Fibrillation
• Interventions: Procedure: circumferential pulmonary vein isolation; Procedure: Linear ablation in addiction to circumferential pulmonary vein isolation

• Registration Number: NCT02721121
• Lead Sponsor: Yonsei University

Brief Summary

The purpose of this study is to compare the clinical outcomes depending on catheter ablation strategy for persistent atrial fibrillation. After randomization, investigators will conduct circumferential pulmonary vein isolation alone in a group, and additional posterior box isolation and anterior linear ablation in the other group. Investigators will compare clinical recurrence rate, complication rate, and procedure time, etc.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-03
• Study First Submitted: 2016-03-22
• Study First Submitted QC: 2016-03-25
• Study First Posted: 2016-03-28
• Status Verified: 2019-01
• Last Update Submitted: 2019-01-18
• Last Update Posted: 2019-01-22
• Primary Completion: 2021-03
• Study Completion: 2021-03

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 220

Inclusion Criteria

• Patients with persistent Atrial fibrillation (20~80 years)
• LA diameter <55mm
• patients possible to anticoagulation and anti arrhythmic drug

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Exclusion Criteria

• Structural cardiac disease
• Contraindication to brain perfusion CT
• Catheter ablation history for AF,
• Cardiac surgery for AF
• active internal bleeding
• Impossible to anticoagulation or antiarrhythmic drug
• valvular AF (MA> GII, Mechanical valve, Mitral valve replacement)
• Patients with severe medical disease
• Expected survival < 1year
• Severe alcoholics, drug addiction

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
circumferential pulmonary vein isolation	circumferential pulmonary vein isolation	circumferential pulmonary vein isolation
Linear ablation in addiction to pulmonary vein isolation	Linear ablation in addiction to circumferential pulmonary vein isolation	Linear ablation in addiction to pulmonary vein isolation

Primary Outcome Measures

Name	Time	Method
Recurrence of atrial fibrillation after catheter ablation	12 month

Secondary Outcome Measures

Name	Time	Method
rate of hospitalization	12 month
procedure related complication rate	12 month
procedure time	1 day

Trial Locations

Locations (1)

Severance Cardiovascular Hospital, Yonsei University Health System; 🇰🇷 Seoul, Korea, Republic of