Efficacy mouthwash developed with vegetable oils

Phase 1

• Conditions: Q65.040; Dental plaquePrevention and control; C07.793.208.377

• Registration Number: RBR-8nr8xy
• Lead Sponsor: niversidade Federal do Pará

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-12-18
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruitment completed
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Be between 18 and 30 years old; both sexes; presence of at least 70% of teeth in the arches; absence of oral pathologies not related to the dental biofilm; present at least 40% of biofilm in the dental faces evidenced in the initial examination.

Exclusion Criteria

Smoking; pregnants; recent or current use of antibiotics and medicines that alter salivary flow; being on radiotherapy or chemotherapy; present systemic diseases that generate oral manifestations; presence of periodontal disease or active carious lesions; presence of dental calculus; make use of orthodontic appliance or occlusal plates; do not accept to signing the free and informed consent form.

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
It is expected to reduce the mean of the dental biofilm deposited on the dental surfaces after 21 days, when compared to the initial plaque index (measured at time 0), by intervention groups that will use chemical agents such as mouthwashes.;The experimental oral rinse with vegetable oils, tested in Group 2 of intervention, is expected to reduce plaque in a quantity equal to or greater than the other chemical agents used in intervention groups 1 and 3.;The mouth rinses tested in intervention groups 1, 2 and 3 are expected to be able to further reduce the amount of bacterial plaque when compared to intervention group 4, which will not use chemical agents for plaque control.

Secondary Outcome Measures

Name	Time	Method
It is expected that the evaluated products do not cause adverse effects on the sample during the study period, as well as that the experimental oral rinse with vegetable oils is well accepted and well tolerated by the research volunteers.