The Neurobiological basis of persisting fatigue and cognitive complaints as a consequence from COVID-19

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 200

Inclusion Criteria

In order to be eligible to participate in this study, a subject must meet all
of the following criteria:
- At least 3 months after diagnosis of COVID-19 (hospitalized or
non-hospitalized) confirmed by a positive PCR for SARS-CoV-2, positive
SARS-CoV-2 serology or CO-RADS (COVID-19 Reporting and Data System) >=4 on
CT-scan, or antigen quicktest.
For post COVID-19 participants with long-term fatigue and cognitive complaints
- Experience severe fatigue after going through COVID-19 (>40 on the fatigue
scale of the Checklist Individual Strength (CIS)(Worm-Smeitink et al., 2017))
- A score of >=18 on the concentration subscale of the CIS, at least 3 months
after COVID-19
For post-COVID-19 participants without persisting fatigue and/or cognitive
complaints
- No severe fatigue on the Checklist Individual Strength (CIS)(Worm-Smeitink et
al., 2017)) (score <=34 on the fatigue scale)
- No substantial cognitive complaints <=18 on the concentration subscale of
the CIS) at least 3 months after COVID-19.

Exclusion Criteria

Subject who meets any of the following criteria will be excluded from
participation in this study:
- Known psychiatric or somatic conditions prior to COVID-19 that could explain
the fatigue or cognitive symptoms.
- Disabling fatigue and/or cognitive complaints prior to COVID-19.
- Re-infection with SARS-CoV-2 within the last 3 months

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Persistent fatigue and cognitive complaints </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>2. Impact of persistent complaints on health-related quality of life, health<br /><br>care consumption<br /><br>3. Risk factors for persistent fatigue and cognitive problems: cognitive<br /><br>behavioural factors (coping, illness perceptions) , cognitive<br /><br>neuropsychological functioning sociodemographic factors (eg. age, gender),<br /><br>medical factors (severity of initial covid19 infection, ICU admission,<br /><br>vaccination status, comorbidity, covid19 virus variant)<br /><br>4. Post-exertional malaise </p><br>