Combined Nerve Blockade and Local Infiltration Anesthesia in Appendectomy - A Blinded Randomized Study

Not Applicable

Completed

• Conditions: Pain, Postoperative
• Interventions: Procedure: local anesthetic administration

• Registration Number: NCT00508092
• Lead Sponsor: Royal Berkshire NHS Foundation Trust

Brief Summary

The purpose of this study is to assess whether the use of local anesthetic to numb the nerves that run deeper in the abdominal wall gives better post operative pain control than just infiltrating local anesthetic to the wound edges.

Detailed Description

Local anesthetic is often administered during an operation to reduce post operative wound pain. Whilst this is frequently done during an appendectomy there is currently no evidence to suggest whether there is any benefit to the patient to injecting the local anesthetic deeper to block the nerves supplying abdominal wall sensation, compared to using it just in the skin around the wound.

Comparison: Post operative pain scores following appendectomy for patients given skin infiltration of local anesthetic (pre incision), compared to patients given both preincision wound infiltration and deeper field infiltration with local anesthetic(deep to external oblique).

Study Timeline

• Study Start: 2007-01
• Study First Submitted: 2007-07-26
• Study First Submitted QC: 2007-07-26
• Study First Posted: 2007-07-27
• Status Verified: 2008-04
• Last Update Submitted: 2008-04-22
• Last Update Posted: 2008-04-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

• Lanz incision appendectomy as starting procedure, including those where an alternative cause for symptoms is found at operation and those where incision is later extended/changed (these may be sub grouped at time of analysis)
• Consent obtained

Exclusion Criteria

• Laparoscopic appendectomy
• Appendectomy at time of laparotomy/other incision

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
A	local anesthetic administration	lanz incision appendectomy
B	local anesthetic administration	lanz incision appendectomy

Primary Outcome Measures

Name	Time	Method
Post operative pain score	1 hour, 4 hours, 8 hours, 24 hours and on discharge

Secondary Outcome Measures

Name	Time	Method
Post operative nausea and vomiting	1 hour, 4 hours, 8 hours, 24 hours and on discharge

Trial Locations

Locations (1)

Royal Berkshire Hospital; 🇬🇧 Reading, Berkshire, United Kingdom