Duration of Blockade of Peripheral Nerves With Low Concentrated Bupivacaine Solution Depending of the Adjuvants
Overview
- Phase
- Not Applicable
- Intervention
- Bupivacaine, dexamethasone, epinephrine
- Conditions
- Postoperative Pain
- Sponsor
- Lviv National Medical University
- Enrollment
- 68
- Locations
- 1
- Primary Endpoint
- The duration of blockade
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
The main aim of the investigator's study is to propose combination of local anesthetics and adjuvants that provides both adequate anesthesia during surgery and prolonged post-operative analgesia.
Detailed Description
Peripheral nerve plexuses blocks are performing as a component of analgesia in patients undergoing orthopedic surgery on the upper or lower extremities. Patients are divided into two groups depending on the adjuvant to the local anesthetic: 1st group - patients whose blockade is performed with a solution of bupivacaine 0.375% together with dexamethasone 0.02%; Group 2 - patients whose blockade is performed with a solution of bupivacaine 0.375% together with dexamethasone 0.02% and epinephrine 0.00018%. The duration of the blockade is estimated by puncturing the skin with a needle. The intensity of pain is assessed at 6, 12, 24 and 36 hours after blockade using Visual analog scale (VAS). The amount of narcotic anesthetic used in the postoperative period is also recorded. In addition, patients underwent electromyography of the innervation area of the blocked nerve before the surgery and 24 and 36 hours after surgery.
Investigators
Maksym Barsa
Principal Investigator
Lviv National Medical University
Eligibility Criteria
Inclusion Criteria
- •All patients undergoing upper or lower extremity orthopedic surgery
Exclusion Criteria
- •diabetes mellitus;
- •diseases of the peripheral nerv system
Arms & Interventions
Bupivacaine with dexamethasone
Ultrasound guided peripheral nerve block for upper or lower extremity was performed before orthopedic surgery using neurostimulator. Twenty milliliters solution of bupivacaine 0,375% with dexamethasone was injected for one plexus or peripheral nerve.
Intervention: Bupivacaine, dexamethasone, epinephrine
Bupivacaine with dexamethasone and epinephrine
Ultrasound guided peripheral nerve block for upper or lower extremity was performed before orthopedic surgery using neurostimulator. Twenty milliliters solution of bupivacaine 0,375% with dexamethasone 0,02% and epinephrine 0,00018% was injected for one plexus or peripheral nerve.
Intervention: Bupivacaine, dexamethasone, epinephrine
Outcomes
Primary Outcomes
The duration of blockade
Time Frame: 6th, 12th, 24th and 36th hours after blockade
The duration of the blockade was estimated by puncturing the skin with a needle every hour. In addition, patients underwent electromyography of the innervation area of the blocked nerve before the surgery and 24 and 36 hours after surgery.
Secondary Outcomes
- The amount of narcotic anesthetic used in the postoperative period(48 hour after surgery)