The effect of a mixed Chinese herbal formula on the immune system of people who have perennial allergic rhinitis, a condition where the immune system overreacts to year-round allergens and causes symptoms like sneezing and congestion in the nose

Phase 2

Completed

• Conditions: Treatment with a mixed Chinese herbal formula for patients with allergic rhinitis; Ear, Nose and Throat

• Registration Number: ISRCTN22925852
• Lead Sponsor: Taoyuan Chang Gung Memorial Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2017-07-31
• Study Start: 2023-06-07
• Last Update Posted: 20 June 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 49

Inclusion Criteria

1. A clinical history of perennial allergic rhinitis characterized by rhinorrhea, sneezing, nasal itching, or nasal obstruction, occurring for an hour or more on most days throughout the year
2. Hypersensitivity to dust mite allergens or other common allergens, as confirmed using a multiple allergen simultaneous test in the high total serum IgE levels (= 200 IU/mL) group
3. Male and female patients aged 20 to 65 years
4. Willing to take medicine as scheduled in this study
5. Volunteered for study enrollment and signed informed consent

Exclusion Criteria

1. Diagnosed as active infectious diseases, such as acute sinusitis, pneumonia, or bronchitis
2. Severe organ dysfunction, such as impaired renal and hepatic function at initial diagnosis (including chronic kidney disease stages III, IV, and V and AST, ALT = 3 × the upper normal limit), liver cirrhosis, or heart failure
3. Using antihistamine, steroid, leukotriene inhibitors, immunosuppressant, or other Chinese herbal medicine for 1 month before enrollment
4. Women who are pregnant or are planning to conceive

Study & Design

• Study Type: Interventional
• Study Design: Not specified