A prospective study conducted in an adult intensive care unit to measure the plasma concentration of citrate during continuous renal replacement therapy.

Not Applicable

Recruiting

• Conditions: Acute kidney failure; Renal and Urogenital - Kidney disease

• Registration Number: ACTRN12616000515493
• Lead Sponsor: Sunshine Coast University Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-04-21
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Clinical requirement for CRRT in patients admitted to the Intensive Care Unit (ICU).

Exclusion Criteria

Age under 18 years
Patients who are pregnant
Patients with advanced liver disease (Childs C)
Patients likely to die within 24 hours of admission the the ICU
Known hypersensitivity or allergy to citrate compounds

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Quantification of plasma citrate concentration.[For the duration of CRRT.<br>Measurements will be taken at 0600hrs, 1400hrs and 2200hrs each day.]

Secondary Outcome Measures

Name	Time	Method
Serial assessment of citrate clearance across the haemofilter.<br>Clearance (C) will be calculated using the simultaneous values for ultrafiltrate concentration (U), plasma concentration (P) and ultrafiltrate flow rate (F) as C = UxF/P.[For the duration of the CRRT.<br>Ultrafiltrate will be sampled at the same times as the plasma samples are taken, that is, 0600hrs, 1400hrs and 2200hrs each day. ]