The effect of direct application of tranexamic acid at the end of sinus surgery on patient recovery

Not Applicable

Completed

• Conditions: Chronic rhinosinusitis; Surgery - Other surgery; Respiratory - Other respiratory disorders / diseases

• Registration Number: ACTRN12619001512112
• Lead Sponsor: The University of Auckland

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-11-01
• Study Completion: 2021-04-28
• Last Update Posted: 20 September 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Adult patient undergoing comprehensive bilateral endoscopic sinus surgery for the treatment of idiopathic chronic rhinosinusitis as defined by the EPOS 2012 guidelines

Exclusion Criteria

Use of tranexamic acid contraindicated owing to history of clotting disorder or thromboembolic disease.
Condition which is know to predispose to chronic rhinosinusitis (e.g. cystic fibrosis, vasculitis, primary ciliary dyskinesia)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
% reduction in patient reported 22-item sino-nasal outcome tool (SNOT-22)[3 months post-operative]

Secondary Outcome Measures

Name	Time	Method
Modified Lund-McKay Postoperative Endoscopic Score (MLMES)[3 months post-operative];Number of days after surgery when patient returns to full work or normal duties as reported by patient[Post-operative];Patient reported severity of bleeding using Likert scale[24 hours after surgery];Complications as reported by the patient, specifically any thromboembolic events[28 days post-operative];% reduction in patient reported 22-item sino-nasal outcome tool (SNOT-22)[2 weeks after surgery];Modified Lund-McKay Postoperative Endoscopic Score (MLMES)[2 weeks after surgery]