Attenuation of pressor response to pneumoperitoneum in laparoscopic surgeries, comparison between magnesium sulphate and dexmedetomidine.A randomized control study.
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 56
- 试验地点
- 1
- 主要终点
- Stastical analysis of the data will be performed using SPSS 20.0, descriptive statistics of SBP,DBP, MBP,and HR will be expressed using mean ± SD. Catagorical variables will be expressed as frequency and percentage. Pre and Post comparison within group will be done using Paired T test. Between the group comparison in all the parameters will be done using unpaired t test . A value 0.05 will be considered statistically significant.
研究概览
简要总结
This study is a randomized controlled trial designed to compare the effectiveness of magnesium sulfate and dexmedetomidine in reducing the pressor response (elevated blood pressure and heart rate) that occurs during pneumoperitoneum in laparoscopic surgeries. The trial aims to determine which of these two interventions better mitigates the cardiovascular changes associated with the insufflation of gas into the abdominal cavity. Participants undergoing laparoscopic procedures will be randomly assigned to receive either magnesium sulfate or dexmedetomidine, and their pressor responses will be measured and compared to identify the more effective treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- None
入排标准
- 年龄范围
- 20.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •1 Patients undergoing laparoscopic surgeries under general anaesthesia.
- •2 ASA 1 and 2.
排除标准
- •1 Patients with abnormal ECG, difficult airway 2 Patients with pre existing disease effecting NMJ 3 Patients with pre existing cardiac, renal, hepatic, cerebral diseases 4 Patients with seizure disorder, electrolyte abnormality 5 Patients with psychiatric disorders.
结局指标
主要结局
Stastical analysis of the data will be performed using SPSS 20.0, descriptive statistics of SBP,DBP, MBP,and HR will be expressed using mean ± SD. Catagorical variables will be expressed as frequency and percentage. Pre and Post comparison within group will be done using Paired T test. Between the group comparison in all the parameters will be done using unpaired t test . A value 0.05 will be considered statistically significant.
时间窗: systolic blood pressure, diastolic blood pressure, mean blood pressure and heart rate are be documented at baseline, 1st min, 5th min, 10th min, 30th mins, 60th min, and at the end of surgery
次要结局
- To compare which drug is better suitable for laparoscopic surgeries.(by measuring hemodynamic parameters at time intervals at baseline,1st min,5th min, 10th min, 30 mins, 60 mins)
研究者
Ratan A Nalatwadmath
Shri devaraj urs medical college