Pre-infarction Angina and Culprit Plaque Characteristics in Patients With STEMI
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Acute Myocardial Infarction
- Sponsor
- Harbin Medical University
- Enrollment
- 305
- Locations
- 1
- Primary Endpoint
- Difference in culprit lesion morphologies assessed by OCT according to the presence or absence of PIA
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
This study aimed to evaluate the incidence of preinfarction angina in AMI patients and test the hypothesis that different clinical presentations before AMI onset can affect coronary plaque morphologies in AMI patients .
Detailed Description
Patients with AMI who underwent primary percutaneous coronary intervention（PCI） and optical coherence tomography (OCT) examination is expected to be included in this study.Data about history were prospectively collected by a standard questionaire ,especially regarding the detail information about preinfarction angina.The basic clinical characteristics,angiographic and OCT findings are compared between patients with and without preinfarction angina.
Investigators
Yu Bo
Director of Cardiology of The 2nd Affiliated Hospital of Harbin Medical University
Harbin Medical University
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- •Patients cant afford medical history;
- •Cardiac shock；
- •Severe left ventricular dysfunction;
- •Left main disease;
- •Hepatic or kidney dysfunction;
- •OCT was performed after predilation;
- •Poor OCT image or massive thrombus.
Outcomes
Primary Outcomes
Difference in culprit lesion morphologies assessed by OCT according to the presence or absence of PIA
Time Frame: baseline
Plaque rupture was defined by the presence of a cavity formation in the plaque with a discontinuity of the fibrous cap. TCFA was defined as a lipid-rich plaque with a thin fibrous cap thickness of ≤ 65 um.Thrombus was identified by OCT as an irregular mass ≧0.25 mm in diameter protruding into the vessel lumen or attached to the surface of the vessel wall.Culprit lesion features in patients with PIA show a lower incidence of plaque rupture and TCFA compared to those without PIA.
Secondary Outcomes
- In-hospital outcomes after AMI.(baseline)