Pre-infarction Angina and Culprit Plaque Characteristics in Patients With STEMI
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 305
- 试验地点
- 1
- 主要终点
- Difference in culprit lesion morphologies assessed by OCT according to the presence or absence of PIA
研究概览
简要总结
This study aimed to evaluate the incidence of preinfarction angina in AMI patients and test the hypothesis that different clinical presentations before AMI onset can affect coronary plaque morphologies in AMI patients .
详细描述
Patients with AMI who underwent primary percutaneous coronary intervention（PCI） and optical coherence tomography (OCT) examination is expected to be included in this study.Data about history were prospectively collected by a standard questionaire ,especially regarding the detail information about preinfarction angina.The basic clinical characteristics,angiographic and OCT findings are compared between patients with and without preinfarction angina.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- •Patients cant afford medical history;
- •Cardiac shock；
- •Severe left ventricular dysfunction;
- •Left main disease;
- •Hepatic or kidney dysfunction;
- •OCT was performed after predilation;
- •Poor OCT image or massive thrombus.
结局指标
主要结局
Difference in culprit lesion morphologies assessed by OCT according to the presence or absence of PIA
时间窗: baseline
Plaque rupture was defined by the presence of a cavity formation in the plaque with a discontinuity of the fibrous cap. TCFA was defined as a lipid-rich plaque with a thin fibrous cap thickness of ≤ 65 um.Thrombus was identified by OCT as an irregular mass ≧0.25 mm in diameter protruding into the vessel lumen or attached to the surface of the vessel wall.Culprit lesion features in patients with PIA show a lower incidence of plaque rupture and TCFA compared to those without PIA.
次要结局
- In-hospital outcomes after AMI.(baseline)
研究者
Yu Bo
Director of Cardiology of The 2nd Affiliated Hospital of Harbin Medical University
Harbin Medical University