Clinical Presentations Before AMI Onset and Coronary Atherosclerosis

Completed

• Conditions: Acute Myocardial Infarction

• Registration Number: NCT03107624
• Lead Sponsor: Harbin Medical University

Brief Summary

This study aimed to evaluate the incidence of preinfarction angina in AMI patients and test the hypothesis that different clinical presentations before AMI onset can affect coronary plaque morphologies in AMI patients .

Detailed Description

Patients with AMI who underwent primary percutaneous coronary intervention（PCI） and optical coherence tomography (OCT) examination is expected to be included in this study.Data about history were prospectively collected by a standard questionaire ,especially regarding the detail information about preinfarction angina.The basic clinical characteristics,angiographic and OCT findings are compared between patients with and without preinfarction angina.

Study Timeline

• Study Start: 2016-06-01
• Study First Submitted: 2017-03-22
• Study First Submitted QC: 2017-04-04
• Study First Posted: 2017-04-11
• Primary Completion: 2017-06-01
• Study Completion: 2017-06-01
• Status Verified: 2018-05
• Last Update Submitted: 2019-11-27
• Last Update Posted: 2019-12-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 305

Inclusion Criteria

Not provided

Exclusion Criteria

1. Patients cant afford medical history;
2. Cardiac shock；
3. Severe left ventricular dysfunction;
4. Left main disease;
5. Hepatic or kidney dysfunction;
6. OCT was performed after predilation;
7. Poor OCT image or massive thrombus.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Difference in culprit lesion morphologies assessed by OCT according to the presence or absence of PIA	baseline	Plaque rupture was defined by the presence of a cavity formation in the plaque with a discontinuity of the fibrous cap. TCFA was defined as a lipid-rich plaque with a thin fibrous cap thickness of ≤ 65 um.Thrombus was identified by OCT as an irregular mass ≧0.25 mm in diameter protruding into the vessel lumen or attached to the surface of the vessel wall.Culprit lesion features in patients with PIA show a lower incidence of plaque rupture and TCFA compared to those without PIA.

Secondary Outcome Measures

Name	Time	Method
In-hospital outcomes after AMI.	baseline	Infarct size was measured as the peak cardiac troponin I (cTnI) level.PIA is associated with lower infarct size and lower in-hospital mortality.

Trial Locations

Locations (1)

The 2nd Affiliated Hospital of Harbin Medical University; 🇨🇳 Harbin, Heilongjiang, China