Endometriosis and Risk Factors in Pregnancy, Labor and Delivery
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Endometriosis
- Sponsor
- Azienda Ospedaliero-Universitaria di Modena
- Enrollment
- 350
- Locations
- 1
- Primary Endpoint
- Gestational diabetes
- Last Updated
- 5 years ago
Overview
Brief Summary
The purpose of this study is to assess if endometriosis can be considered a risk factor for adverse obstetric and delivery outcomes
Detailed Description
This is a retrospective, observational, case-control study. Pregnancy, delivery and neonatal outcomes will be analyzed in two groups of patients (case and control group): women with diagnosis of endometriosis histologically confirmed and women without endometriosis. Women with endometriosis will be matched to controls by age. A database with general medical and gynecological history, pregnancy course, delivery mode and newborn conditions will be analyzed.
Investigators
Carlo Alboni, MD, PhD
Dr. Carlo Alboni MD, PhD Head of Minimally Invasive and Robotic Gynecologic Surgery Unit University Hospital of Modena - Italy
Azienda Ospedaliero-Universitaria di Modena
Eligibility Criteria
Inclusion Criteria
- •Pregnant women who delivered at Azienda Ospedaliero Universitaria Policlinico di Modena from 2000 to 2020
- •Histologic diagnosis of endometriosis before pregnancy for case group
- •Age matched healthy patients for control group
Exclusion Criteria
- •Clinical records not available
Outcomes
Primary Outcomes
Gestational diabetes
Time Frame: after 18 weeks' pregnancy
fasting blood glucose \>17 mmol/L
Postpartum hemorrhage
Time Frame: Time of delivery
Greater than 500 mL estimated blood loss in a vaginal delivery or greater than 1000 mL estimated blood loss at the time of cesarean delivery
Birth-weight
Time Frame: Time of delivery
small for gestational age (birth weight below the 10th percentile) or large for gestational age (birth weight over the 90th percentile)
Preterm delivery
Time Frame: Time of delivery
Incidence of delivery before 37 weeks of pregnancy
Gestational hypertension
Time Frame: after 20 weeks' gestation
blood pressure persistently \> 140/90 mm Hg
Assisted reproduction technologies
Time Frame: before pregnancy
Patients who referred to assisted reproduction technologies
Cesarean Section
Time Frame: Time of delivery
Robson Classifications
Apgar scores
Time Frame: Time of delivery
Apgar scores