Longitudinal Study of Dental Implant Therapy in HIV Positive Patients

Not Applicable

Completed

Brief Summary: The purpose is to place implants in HIV positive and HIV negative patients then follow patients over 3 years period of time to evaluate how well dental implants perform in HIV positive patients versus HIV negative patients.

Detailed Description: This study will review the osseointegration of implant supported restorations in HIV positive and HIV negative patients, then follow patients over a 3 year period of time. The treatment outcome as measured according to Mish criteria for implant success. Patients will be examined at each interval for the presence of pain, infection, mobility, and radiographic bone height of each implant.

Recruitment & Eligibility

Inclusion Criteria

Healthy enough to undergo the proposed therapy without compromise to existing health status
At least 19 years old
Able to read and understand written English without the aid of ad hoc interpretation
Able to cognitively understand the proposed study and therapy and possible prognoses
Able to consent for their own inclusion in the study.
Implant supported restorations are limited to the following edentulous areas: Mandibular arch (excluding 2nd and 3rd molar areas), Maxillary anterior and premolar areas

Exclusion Criteria

Smoker
Uncontrolled diabetes
Uncontrolled hypertension
Bisphosphonate user
Bruxer
Extraction site healed less than 6 months
Women pregnant or lactating at the time of enrollment
Previous malignant neoplasm
A known hypersensitivity to Titanium metal
Any medication/condition that in the opinion of the clinical investigators may adversely affect bone healing
Any indication of an inability to make autonomous decisions

Arm && Interventions

Group	Intervention	Description
HIV negative group	Astra implants	This group contains participants consented to receive implants and identified as negative for HIV
HIV positive group	Astra implants	This group contains participants consented to receive implants and identified as positive for HIV

Primary Outcome Measures

Name	Time	Method
Number of Implants Functioning in HIV Positive Subjects Compared to HIV Negative Subjects	Baseline to 36 months after implant restoration complete	Dental implant supported restoration functioning in the mouth with no pain, no mobility, no infection and less than 50% bone loss around the implant site.

Secondary Outcome Measures

Name	Time	Method
Peri-implant Health and Bone Maintenance as Measured by Radiographic Examination in HIV Positive Subjects Compared to HIV Negative Subjects	36 months after implant restoration	Radiographic examination of implant osseointegration and bone loss by using traditional periapical and /or bitewing radiographs.