Optimising treatment outcomes for children and adults through rapid genome sequencing of sepsis pathogens. A study protocol for a prospective, multi-centre trial (DIRECT)

Not Applicable

• Conditions: Sepsis; Antimicrobial resistance; Infection - Studies of infection and infectious agents

• Registration Number: ACTRN12620001122943
• Lead Sponsor: The University of Queensland

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-10-30
• Last Update Posted: 9 November 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

1.Admitted to paediatric or adult ICU at one of the participating centres
2.Decision to treat for suspected sepsis, defined as suspected or proven infection with suspected or proven organ dysfunction.
3.Commenced within 24h on intravenous broad-spectrum antibiotics, or within 24h of a change to new antibiotics consistent with treatment for a new episode of suspected sepsis.
4.Blood cultures are being obtained or were obtained within the past 12 hours

Exclusion Criteria

1.Inability to gain informed consent during the study period
2.Neonates
3.Death is likely imminent
4.Palliative care patient

Study & Design

• Study Type: Interventional
• Study Design: Not specified