The effect of Sylimarine on reduction of liver size and fatty liver grade in sonography among laparoscopic bariatric surgery candidates

Phase 3

Recruiting

• Conditions: Morbid Obesity.; Morbid (severe) obesity due to excess calories; E66.01

• Registration Number: IRCT20190128042520N1
• Lead Sponsor: Iran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 21 May 2019

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 56

Inclusion Criteria

Patient with morbid obesity(BMI>40 or BMI>35 with comorbidity
18 to 60 years old patient

Exclusion Criteria

Patients who are not willing to attend the study
Patients are taking omega 3 pearl.
Patients who have allergy to any herbal drugs
Patients should to use warfarin or midazolam .
Patients are doing sever physical activity.
Patients use alcohol
Patients who had low or very low calorie diet.
Patients use distillates such as chicory or milk thistle
Patients who have cirrhosis or hepatitis.
Patients who have ALT more than 5 fold increase in normal level(7-56 units)

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mean of liver size. Timepoint: Liver measurement at first of study and after finalization of silymarin(1 month). Method of measurement: With sonography to mm.;Mean of fatty liver grade. Timepoint: Fatty liver grade at first of study and after finalization of silymarin(1 month). Method of measurement: Sonography.;Mean of Liver function test. Timepoint: Liver function test measurement at first of study and after finalization of silymarin(1 month). Method of measurement: Laboratory kit.