Efficacy of Anti-dry cream in treatment of hand eczema

Phase 2

Conditions: Hand eczema.
ICD-10: L3
ICD-10: Dermatitis unspecified Eczema NOS

Registration Number: IRCT201212303734N2

Lead Sponsor: Barij Essence Herbal Medicine Research Center

Brief Summary: Abstract: Introduction: Hand eczema is the most common dermatitis that affects hands. The annual prevalence of hand eczema has been reported to be between 7 and 12 percent. Due to the physical and psychological effects of hand eczema, failure of existing treatment methods and corticosteroids side effects the current study has been designed to assess the effect of anti-dry cream on treatment of hand eczema symptoms and compare it with fluocinolone acetonide cream 0.025. Material and method: This study is a double-blind randomized clinical trial and has been conducted on hand eczema sufferers. Random allocation using the block method was assigned to two groups; anti-dry cream and fluocinolone acetonide cream 0.025.drug is applied for two weeks, twice daily, and in each time massaging cream gently into the position.Subjects were evaluated at the baseline and two weeks after treatment in terms of clinical symptoms and possible complications. Findings: In this study, 73 patients were studied out of which 16 were male and the rest were female. Distribution in terms of gender, age, education, occupation, duration of illness, frequency of disease occurrence, medications and personal and family medical history were similar in both groups.(p>0.05)The results showed a decrease in score of disease In anti dry group after treatment in left and right hands, it was 3.94and 5.07 and for fluocinolone group it was 4.12 and 4 respectively. So there was no significant difference between two groups (p>0.11) Conclusions: The results of this study indicate the therapeutic effects of anti- dry and fluocinolone cream. With regard to the lack of difference between the two groups, anti –dry cream can be used as an alternative treatment for hand eczema. Keywords: Anti -dry, Fluocinolone acetonide, hand eczema Introduction:

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 108

Inclusion Criteria

Main inclusion criteria: age between 18-75y/o; patients should be eager to participate in trial; patients with hand eczema that is confirmed by dermatologist.
Main exclusion criteria: pregnancy and lactation; application of topical drugs during previous two weeks; systemic therapies such as corticosteroids, immunosupressive drugs and antibiotics during the past 4 weeks; localized hand infection; history of allergic reaction to the study medications.

Exclusion Criteria

Not provided

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change of signs and symptoms of hand eczema. Timepoint: The days of 0 and 14. Method of measurement: Questionnaire (contains of clinical signs and symptoms: erythema, scaling, lichenification/ hyperkeratosis, edema,vesicle, fissure, pruritus and pain).

Secondary Outcome Measures