What are the levels of ketone bodies in adult patients who are fasting for either elective or emergency surgeries in an Australian tertiary hospital?

Not Applicable

Recruiting

• Conditions: ketoacidosis; starvation ketosis; Anaesthesiology - Anaesthetics; Metabolic and Endocrine - Normal metabolism and endocrine development and function

• Registration Number: ACTRN12619001622190
• Lead Sponsor: Royal Perth Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-11-22
• Last Update Posted: 21 September 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

Adult patients > 18 years of age
American Society of Anaesthesiologist (ASA) physical scale 1-4
Elective or emergency surgeries under general anaesthesia OR local/regional anaesthesia when the patient is fasted preoperatively.

Exclusion Criteria

Unable to provide informed consent
People whose primary language is other than English
Emergency surgeries of very high urgency such that the time needed to obtain consent for study could, in study team’s opinion, affect clinical outcome

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Quantification of the extent of preoperative ketonaemia in fasting adult surgical patients undergoing elective and emergency surgeries. This is measured via a point-of-care blood ketone meter using small blood sample. [Immediately before commencement of surgery. ]

Secondary Outcome Measures

Name	Time	Method
Acid-base status as assessed by blood gas analysis in subgroup of patients found to have preoperative blood ketone level of 0.6 mmol/L or above. [Immediately before surgery. ];Postoperative ketonaemia in fasting adult surgical patients undergoing elective and emergency surgeries. This is measured via a point-of-care blood ketone meter using small blood sample. [Immediately at the end of surgery];Acid-base status as assessed by blood gas analysis in subgroup of patients found to have preoperative blood ketone level of 0.6 mmol/L or above. [Immediately at the end of surgery]