A Prospective randomized controlled study on comparison of intravenous Ibuprofen and Paracetamol for post operative pain relief in functional endoscopic sinus surgeries (FESS)
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Duration of Post operative analgesia
研究概览
简要总结
This study will be performed in patients scheduled to undergo FESS surgery under general anesthesia. A written informed consent will be obtained from the participants. The participants will be allocated into two groups by computer-generated random numbers group I is Ibuprofen and group P is paracetamol. Anaesthesia premedication and induction will be standardized among two groups. The surgeon will be asked to infiltrate with plain adrenaline not xylocaine with adrenaline for local site infiltration. ibuprofen 400mg and paracetamol 1gm will be administered in the respective groups 15 min before the end of the procedure and patient will be shifted to post anaesthesia care unit and pain intensity will be monitored using VAS score for 24 hrs. if the VAS score >4 ibuprofen and paracetamol will be repeated in the respective groups and inj.tramadol 100mg iv will be administered if needed as a second rescure analgesic.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)(—)
- 性别
- All
入选标准
- •ASA 1 and ASA 2 Patients patient weight between 50 to 80 kg.
排除标准
- •Hepatic disease and renal disorders History of GERD and peptic ulcer History of drug allergy patient with coagulation abnormality.
结局指标
主要结局
Duration of Post operative analgesia
时间窗: assessment of VAS score at 0hour,4hours,8hours,12hours, 16hours,20hours and 24 hours,
次要结局
- VAS score during first 24 hrs of postoperative period(Total amount of NSAID used)
研究者
Dr LGeetha Ramalakshmi
SRM Medical college hospital and research centre
