Physical Exercise and Pollution: Cardiorrespiratory, Cerebral and Molecular Aspects

Phase 4

Completed

• Conditions: Cognitive Function 1, Social
• Interventions: Other: Physical Exercise

• Registration Number: NCT02304731
• Lead Sponsor: Federal University of São Paulo

Brief Summary

Modern society increasingly seeks healthy life style, and regular physical activity is considered one of the main factors that improve the quality of life. The evidence shows that the aerobic physical training in controlled environments benefit various aspects of human health, including cognition in the elderly population. However, when exercise is performed in a polluted environment, the individual is subjected to grater exposure to pollutants due to increased ventilation (breathing).

Detailed Description

Modern society increasingly seeks healthy life style, and regular physical activity is considered one of the main factors that improve the quality of life. The evidence shows that the aerobic physical training in controlled environments benefit various aspects of human health, including cognition in the elderly population. However, when exercise is performed in a polluted environment, the individual is subjected to grater exposure to pollutants due to increased ventilation (breathing). It is well known that inhaled pollutants can cause oxidative modification in biomolecules and oxidative stress is a cause of diverse diseases. This scenario raises important questions: the deleterious effects of pollution can abolish the beneficial effects of exercise? This issue is currently relevant given the increasing level of air pollution in large urban centers such as Sao Paulo city and at the same time, outdoor physical activity in public places is largely stimulated by public organizations, particularly for elderly. Thus this multidisciplinary project aims to investigate the deleterious effects of urban air pollution in elderly people who practice aerobic physical exercise outdoors in Sao Paulo and compare with those who practice in Laboratory. This study can provide important knowledge for public health and welfare of the population.

Study Timeline

• Study Start: 2013-02
• Primary Completion: 2013-12
• Study Completion: 2014-07
• Status Verified: 2014-11
• Study First Submitted: 2014-11-27
• Study First Submitted QC: 2014-11-27
• Last Update Submitted: 2014-11-27
• Study First Posted: 2014-12-02
• Last Update Posted: 2014-12-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

Health Subjects that lives in São Paulo city for at least 10 years.

Exclusion Criteria

Neuropsychological issues.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Exercise and Pollution Groups	Physical Exercise	Physical Exercise performed in a clean environment and in a polluted environment.

Primary Outcome Measures

Name	Time	Method
Cognitive Benefits	12 weeks	Neuropsychological Tests applied at the beginning and at the end of protocol