Vascular reactivity as a surrogate marker in CADASI
- Conditions
- hereditary vascular dementia1000796310047066
- Registration Number
- NL-OMON45639
- Lead Sponsor
- eids Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 46
- participant in baseline 2000 study (P80/98)
- Aged above 18 years
- NOTCH3 mutation status known OR partner of a CADASIL patient
contra-indication for MRI scanning:
- Claustrophobia
- Pacemakers or defibrillators
- Nerve stimulators
- Intracranial clips
- Intraorbital or intraocular metallic fragments
- Cochlear implants
- Ferromagnetic implants
- Hydrocephalus pump
- Intra-utrine device (not all types)
- Permanent make-up
- Tattoos above the shoulders (only those older than 20 years);Contra- indication for fMRI:
- Seizure within prior year.
- Non-correctable visual impairment.;Contra- indications for acetazolamide challenge:
- Steven-Johnsons syndrome
- Individuals from Japanese or Indian descent
- Known allergy to sulphonamides
- Known severe liver or renal insufficiency
- Known occlusion of the a. vertebralis, basilaris or carotis
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Differences in vascular reactivity between CADASIL patients and controls<br /><br>Correlation between vascular reactivity measurements and clinical severity<br /><br>(scores on neuropsychological and disability scales, age at first stroke)<br /><br>Correlation between vascular reactivity measurements and MRI parameters (number<br /><br>of lacunar infarcts, brain atrophy)</p><br>
- Secondary Outcome Measures
Name Time Method <p>Correlation between changes in vascular reactivity over a 17-year timeframe and<br /><br>disease progression. Correlation between other candidate markers (skin NOTCH3<br /><br>score, serum NOTCH3 levels) and disease progression.</p><br>