An exploratory study into the acute and long-term effects of high-protein supplementation on postprandial muscle protein metabolism in healthy elderly.

Completed

• Conditions: Sarcopenia

• Registration Number: NL-OMON27334
• Lead Sponsor: Danone Research – Centre for Specialised Nutrition

Brief Summary

Audrey Chanet, Sjors Verlaan, Jérôme Salles, Christophe Giraudet, Véronique Patrac, Véronique Pidou, Corinne Pouyet, Nordine Hafnaoui, Adeline Blot, Noël Cano, Nicolas Farigon, Anke Bongers, Marion Jourdan, Yvette Luiking, Stéphane Walrand, Yves Boirie; Supplementing Breakfast with a Vitamin D and Leucine–Enriched Whey Protein Medical Nutrition Drink Enhances Postprandial Muscle Protein Synthesis and Muscle Mass in Healthy Older Men, The Journal of Nutrition, Volume 147, Issue 12, 1 December 2017, Pages 2262–2271, https://doi.org/10.3945/jn.117.252510

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 24

Inclusion Criteria

1. Age 65 y or older;

2. Male;

Exclusion Criteria

1. Prior or current participation in any other clinical study using phenylalanine stable isotopes;

2. Indications related to inadequate glycemic control;

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mixed muscle protein fractional synthetic rate (FSR) [%/h].

Secondary Outcome Measures

Name	Time	Method
1. Rate of phenylalanine uptake by the forearm [µmol/100ml.min];<br /><br>2. Rate of phenylalanine release by the forearm [µmol/100ml.min];<br /><br>3. Forearm phenylalanine net balance [µmol/100ml.min].