Interest of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Auditory Hallucinations
- Conditions
- Schizophrenic Disorders
- Registration Number
- NCT02525315
- Lead Sponsor
- University Hospital, Caen
- Brief Summary
Auditory hallucinations are common (present in 60-70% of cases) and extremely debilitating. Behavioral disorders associated with them can have serious social repercussions. However, in 25% of cases the usual antipsychotic drug treatments are incompletely or totally ineffective.
Fifteen subjects will be included after collection and signed their informed consent.
The rTMS treatment is made of 4 sessions of 13 minutes spread over two days, at a frequency of 20 Hz and an intensity of 80% of motor threshold at rest. These constants are used to stay below the risk of occurrence of seizures, the only serious side effects identified. Furthermore the rTMS treatment is almost painless: tension headaches are the main side effects and make amends with simple analgesics. rTMS is devoid of neurocognitive effects. The LEFT stimulation site will be established through a anatomofunctional imaging before treatment (between D-7 and D0).
Treatment efficacy will be evaluated daily during treatment (days 1 and 2) and during the first 2 weeks of starting treatment.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 15
- Patients with schizophrenic disorders aged from 18 to 60 years old
- Patients suffering from auditory hallucinations undergoing antipsychotic treatments
- Written signed consent
- Pregnancy or breastfeeding
- Counter-indication to MRI or to rTMS
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method HOFFMAN score change between baseline and day 3 or day 12
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Caen University Hospital
🇫🇷Caen, France