rTMS for Auditory Hallucinations Guided by Magnetoencephalography
- Conditions
- Schizophrenia
- Interventions
- Device: rTMS and MEG for auditory hallucinations via self controlled clinical trials
- Registration Number
- NCT05598450
- Lead Sponsor
- Shanghai Mental Health Center
- Brief Summary
rTMS and MEG for auditory hallucinations via self controlled clinical trials. Repetitive transcranial magnetic stimulation (rTMS) can increase or decrease cortical excitability in patients with psychosis (such as schizophrenia). Here, we conducted an open clinical trial on 60 schizophrenics with auditory hallucinations. We searched for targets through magnetoencephalography and then intervened to prove that rTMS guided by magnetoencephalography is effective for auditory hallucinations.
- Detailed Description
Before intervention, each patient was scheduled to collect three magnetoencephalogram data sessions. Apply MEG technology to calculate possible locations and determine three intervention targets. Pseudo stimulation in the first week, 5-day intervention, 3 targets per day, each target for 23 minutes, with a 30 minute interval between each target. Evaluate the scale after the first week of pseudo stimulation. Week 2-4 real stimulation, intervention 5 days a week, 3 targets per day, each target for 23 minutes, with a 30 minute interval between each target. After the end of the fourth week, evaluate the scale. And follow-up evaluations will be conducted on the 7th, 14th, 30th, 60th, and 90th days after the intervention.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 60
- Schizophrenia with auditory hallucinations was diagnosed by DSM-IV, AHRS >12, Take sufficient antipsychotics for at least 1 month.
- current pregnancy, major medical illness affecting the central nervous system, significant neurologic disorders, intake of drugs including supplements like essential fatty acids that influence prostaglandins or niacin skin flush flash pathway metabolism, a history of suicide risk, or alcohol or drug abuse.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description schizophrenia patients with auditory hallucinations rTMS and MEG for auditory hallucinations via self controlled clinical trials For schizophrenia patients with auditory hallucinations, rTMS+MEG for implementation intervention
- Primary Outcome Measures
Name Time Method Reduction rate of AHRS scale One month Reduction rate of AHRS scale (the minimum is 0, maximum value is 47, and higher scores mean a worse outcome)
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Shanghai Mental Health Center
🇨🇳Shanghai, China