Refeeding Like Syndrome in Acute Disease

Completed

• Conditions: Refeeding Syndrome; Acute Abdomen

• Registration Number: NCT04966780
• Lead Sponsor: Jens Rikardt Andersen

Brief Summary

The refeeding syndrome has been reported without any evidence of prolopnged semistarvation, thus being different from the traditional disease.

The investigators wanted to investigate, if sodium infusions could be part of the explanation.

Detailed Description

Background: Refeeding syndrome is conventionally connected to start of feeding after prolonged periods of semi-starvation and adaption. However, it is also described in acutely ill patients and in ICU patients without a history of adaption, but sometimes only defined as a drop in p-phosphate without clinical manifestations. The investigators hypothesize, that a positive sodium balance could induce the refeeding-like syndrome (RLS).

Method: Consecutive patients for acute, abdominal surgery were included and observed until discharge or up to seven days postoperatively with daily sodium and phosphate balance measurements.

Study Timeline

• Study Start: 2018-04-01
• Primary Completion: 2021-06-01
• Study Completion: 2021-06-01
• Status Verified: 2021-07
• Study First Submitted: 2021-07-08
• Study First Submitted QC: 2021-07-08
• Study First Posted: 2021-07-19
• Last Update Submitted: 2021-07-19
• Last Update Posted: 2021-07-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

• age > 18 yr
• ready for acute surgery
• able to understand and cooperate.

Exclusion Criteria

• pregnancy or breastfeeding
• renal insufficiency (p-creatinine>400 micr mol/l)
• re-operations
• expected hospital stay < 24 hours.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
sodium balance	7 days	correlation between sodium balance and occurrence of the refeeding syndrome

Secondary Outcome Measures

Name	Time	Method
phosphate balance	7 days	correlation between decline in plasma phosphate and urinary excretion of phosphate
plasma phosphate	7 days	correlation between sodium balance and change in plasma phosphate
urinary excretion of phosphate	7 days	correletion between sodium balance and urinary excretion of phosphate

Trial Locations

Locations (1)

Herlev University Hospital; 🇩🇰 Herlev, Denmark