Evaluation of Ocular Lens Proteins in Cataract From Individuals With Down Syndrome
- Conditions
- Down SyndromeCataract
- Interventions
- Procedure: cataract surgery
- Registration Number
- NCT03778528
- Lead Sponsor
- University of Colorado, Denver
- Brief Summary
This study involves the collection ocular lens tissue from individuals with Down syndrome and age-matched controls at the time of cataract surgery.
- Detailed Description
Individuals with Down syndrome have an increased rate of cataract. The reason for this increase is unclear. Normally, once cataracts become a significant impairment, an ophthalmologist will determine when cataract surgery should be performed. When this surgery is performed, cataractous tissues are cut out and discarded with medical waste. In this study, these tissue will be collected and protein analysis performed to determine what changes in different proteins are found in Down syndrome lenses as compared to normal cataractous lenses.
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 1
- Undergoing cataract surgery for lens extraction.
- Known genetic cause other than Down syndrome causing cataract.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Down syndrome cataract surgery Individuals with Down syndrome undergoing cataract surgery. Control cataract surgery Age-matched controls undergoing cataract surgery.
- Primary Outcome Measures
Name Time Method Change in protein composition one week after collection of tissue western blot analysis of proteins from cataractous tissue
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Children's Hospital of Colorado
🇺🇸Aurora, Colorado, United States