Evaluation of Ocular Lens Proteins in Cataract From Individuals With Down Syndrome

Terminated

• Conditions: Down Syndrome; Cataract

• Registration Number: NCT03778528
• Lead Sponsor: University of Colorado, Denver

Brief Summary

This study involves the collection ocular lens tissue from individuals with Down syndrome and age-matched controls at the time of cataract surgery.

Detailed Description

Individuals with Down syndrome have an increased rate of cataract. The reason for this increase is unclear. Normally, once cataracts become a significant impairment, an ophthalmologist will determine when cataract surgery should be performed. When this surgery is performed, cataractous tissues are cut out and discarded with medical waste. In this study, these tissue will be collected and protein analysis performed to determine what changes in different proteins are found in Down syndrome lenses as compared to normal cataractous lenses.

Study Timeline

• Study Start: 2018-05-30
• Study First Submitted: 2018-12-12
• Study First Submitted QC: 2018-12-14
• Study First Posted: 2018-12-19
• Status Verified: 2020-07
• Primary Completion: 2020-07-01
• Study Completion: 2020-07-01
• Last Update Submitted: 2020-07-01
• Last Update Posted: 2020-07-07

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 1

Inclusion Criteria

• Undergoing cataract surgery for lens extraction.

Exclusion Criteria

• Known genetic cause other than Down syndrome causing cataract.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in protein composition	one week after collection of tissue	western blot analysis of proteins from cataractous tissue

Trial Locations

Locations (1)

Children's Hospital of Colorado; 🇺🇸 Aurora, Colorado, United States