Identifying Undiagnosed Asymptomatic HIV Infection in Hispanic/Latino Adolescents and Young Adults

Completed

• Conditions: HIV
• Interventions: Behavioral: Effectiveness of different strategies in HIV testing and linkage to care

• Registration Number: NCT01203332
• Lead Sponsor: University of North Carolina, Chapel Hill

Brief Summary

The proposed research will include adolescent and young adult Hispanic/Latino men who have sex with men (MSM) and heterosexual men and women, aged 13-24 years, and will be based at 13 ATN Adolescent Medicine Trial Units (AMTUs) that provide clinical care and psychosocial services to the target group. In 10 of the 13 sites, comparisons will be made between alternative venue-based testing (AVT) and social and sexual network-based interviewing and HIV testing (SSNIT) strategies to assess which, among these approaches, is the most effective means for identifying undiagnosed human immunodeficiency virus (HIV) in young, at-risk Hispanics/Latinos. Three of the sites will focus solely on use of SSNIT for identifying undiagnosed HIV in our target group of adolescents and young adults. All study participants will complete an audio computer-assisted self-interview (ACASI) and undergo HIV screening. Participants with presumptive HIV positive screening results will be referred to the local AMTU for confirmatory testing, post-test counseling and referrals for linkage to HIV medical care. Linkage to care for ATN 096 study participants will be conducted in accordance with the Strategic Multisite Initiative for the Identification, Linkage, and Engagement in Care of Youth with Undiagnosed HIV Infection (SMILE in CARING for YOUTH) Program (ATN 093), a collaboration of the CDC and NICHD/ATN, to ensure that youth who test positive for HIV as part of this protocol are linked with treatment and care.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-07
• Study First Submitted: 2010-09-15
• Study First Submitted QC: 2010-09-15
• Study First Posted: 2010-09-16
• Primary Completion: 2013-01
• Study Completion: 2013-01
• Status Verified: 2016-03
• Last Update Submitted: 2017-02-27
• Last Update Posted: 2017-02-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1917

Inclusion Criteria

Not provided

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Alternative Venue Testing (AVT)	Effectiveness of different strategies in HIV testing and linkage to care	Participants recruited for testing through the AVT recruitment method.
SSNIT - Network Member	Effectiveness of different strategies in HIV testing and linkage to care	Participants recruited by someone in their social or sexual network to participate in the study, including HIV testing.
SSNIT - Index Recruiter	Effectiveness of different strategies in HIV testing and linkage to care	Participants recruited for HIV testing and to bring members of their social and sexual network to the study.

Primary Outcome Measures

Name	Time	Method
Effectiveness of AVT strategy with SSNIT	2 years	To compare the relative effectiveness of AVT with SSNIT, which is a coupon-based index recruiter driven network recruitment strategy for identifying previously undiagnosed HIV infection among Hispanic/Latino adolescents and young adults aged 13-24 years.
Facilitators & barriers to HIV testing	2 years	To examine factors that facilitate and/or hinder Hispanic/Latino adolescents and young adults in getting an HIV test (e.g., perceived risk for HIV, acculturation, homophobia, stigma associated with IDU).
Sub-group differences	2 years	To explore the extent to which sub-group differences (e.g., origin of birth, age, level of acculturation) exist by prevalence of HIV-related risk behaviors, HIV testing, and mode of HIV transmission.

Trial Locations

Locations (13)

Childrens Diagnostic & Treatment Center; 🇺🇸 Fort Lauderdale, Florida, United States

Childrens Hospital of Philadelphia; 🇺🇸 Philadelphia, Pennsylvania, United States

University of California San Francisco; 🇺🇸 San Francisco, California, United States

University of Puerto Rico; 🇵🇷 San Juan, Puerto Rico

St. Jude Childrens Research Hospital; 🇺🇸 Memphis, Tennessee, United States

University of South Florida; 🇺🇸 Tampa, Florida, United States

University of Maryland; 🇺🇸 Baltimore, Maryland, United States

University of Miami School of Medicine; 🇺🇸 Miami, Florida, United States

Mount Sinai Medical Center; 🇺🇸 NY, New York, United States

Childrens National Medical Center; 🇺🇸 Washington, District of Columbia, United States

Ruth M Rothstein CORE Center/ John H Stroger Jr Hospital; 🇺🇸 Chicago, Illinois, United States

Childrens Hospital Los Angeles; 🇺🇸 Los Angeles, California, United States

Montefiore Medical Center; 🇺🇸 Bronx, New York, United States