Impact of Aerobic Exercise Training on Age Related Changes in Insulin Sensitivity and Muscle Oxidative Capacity

Mayo Clinic1 site in 1 country102 target enrollmentSeptember 1995

ConditionsAging

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Aging
Sponsor: Mayo Clinic
Enrollment: 102
Locations: 1
Primary Endpoint: Insulin sensitivity
Status: Completed
Last Updated: 14 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

This study randomized healthy sedentary people age 20-80 years to 16 weeks of supervised exercise versus no exercise. Several end points were evaluated after 16 weeks including insulin sensitivity and muscle physiology.

Detailed Description

Healthy subjects performing \< 30 min exercise twice per week were studied prior to randomization and after of sixteen weeks exercise. They were randomized to sixteen weeks of supervised exercise performed on a stationary bike vs. placebo exercise (a series of flexibility exercises performed at home). Intensity, duration and frequency of exercise were gradually increased to four sessions per week lasting forty minutes each and achieving 80% target heart rate. Participants were weighed perioidically and counseled appropriately when weight changed by \> 2 %. Insulin sensitivity and muscle mitochondrial protein synthesis were studied.

Registry

clinicaltrials.gov

Start Date

September 1995

End Date

January 1998

Last Updated

14 years ago

Study Type

Interventional

Study Design

Parallel