Effect of Aerobic Interval Training on Cardiovascular Function in Aging

Not Applicable

Completed

Interventions: Other: High intensity aerobic interval training
Other: Continuous moderate intensity exercise

Brief Summary: Study objectives:

1. To compare cardiovascular function in older compared to young healthy adults.

2. To compare the effect of 8 weeks of aerobic interval training vs. continuous moderate exercise on cardiovascular function in healthy older adults.

Hypotheses:

1. Compared to young adults, older adults will have lower cardiovascular function.

2. Compared to continuous moderate intensity exercise training, interval training will be more effective in improving cardiovascular function in older adults.

Detailed Description: Cardiovascular function will be measured at baseline in older healthy adults and young healthy controls. Older adults will be randomized to the aerobic interval training group, continuous moderate exercise group or non-exercise control group. At the end of the 8-week exercise intervention, baseline measures will be repeated in the older adults.

Recruitment & Eligibility

Inclusion Criteria

Not provided

Exclusion Criteria

history of diabetes
history of any relevant cardiovascular diseases (myocardial infarction, angina pectoris, history of coronary artery bypass surgery or angioplasty, congestive heart failure, or arrhythmia)
hypertension (≥160 mmHg systolic or ≥100 mmHg diastolic)
history of renal impairment
history of gout or hyperuricemia
history of hepatic disease or infection with hepatitis B, C
history of seizures, or other relevant on-going or recurrent illness
recent (within 3 months) or recurrent hospitalizations
use of tobacco products
>5 % weight change in the prior 6 months.
current intake of medications that may affect study results
participation in regular aerobic exercise training (>30 minutes,
- 3 times/wk in the past year).
premenopausal women taking oral contraceptives and postmenopausal women taking hormone replacement therapy.
pregnancy (positive urine pregnancy test) or lactation

Arm && Interventions

Group	Intervention	Description
High intensity aerobic interval training	High intensity aerobic interval training	Older adults will complete 8 weeks of high intensity aerobic interval exercise training.
Continuous moderate intensity exercise	Continuous moderate intensity exercise	Older adults will complete 8 weeks of continuous moderate intensity exercise training.

Primary Outcome Measures

Name	Time	Method
Change in vascular endothelial function	At baseline and after 8 weeks of exercise training	Brachial flow-mediated dilation using ultrasonography

Secondary Outcome Measures

Name	Time	Method
Change in arterial stiffness	At baseline and after 8 weeks of exercise training	Arterial stiffness and wave reflection will be measured using the SphygmoCor device
Change in factors related with endothelial function	At baseline and after 8 weeks of exercise training	Blood and cellular markers of oxidative stress and inflammation
Change in cardiac function	At baseline and after 8 weeks of exercise training	Left ventricular systolic and diastolic function will be measured using echocardiography
Change in maximal oxygen consumption	At baseline and after 8 weeks of exercise training	Maximal oxygen consumption will be measured using online computer-assisted open-circuit spirometry during incremental treadmill exercise

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