NCT01649037撤回不适用
A Randomised, Open Label Study to Compare the Efficacy of Nor Adrenaline and Terlipressin vs Step up Terlipressin Therapy in Hepatorenal Syndrome
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- the Response to treatment in each intervention group
研究概览
简要总结
All consecutive patients with liver cirrhosis having Acute Kidney Injury at admission or during hospitalization will be included in the study.
The diagnosis of liver cirrhosis will be based on the clinical grounds including Laboratory tests, endoscopic evidence, imaging (Ultrasonography/computed tomography) findings, and liver histology, when available.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with Liver cirrhosis and acute kidney injury. Patients consented for the study protocol by signing the informed consent.
排除标准
- •Age less than 18 years Cirrhotics with kidney injury managed as outpatients. Patients undergoing renal replacement therapy (hemodialysis/renal transplantation).
- •Post liver transplantation patients. Hepatocellular carcinoma. History of coronary artery disease, ischaemic cardiomyopathy, ventricular arrhythmia, or peripheral vascular disease.
- •Patients with obstructive uropathy. Patient who withdrew or non complaint to the study protocol.
研究组 & 干预措施
nor adrenaline and terlipressin
Experimental
干预措施: nor adrenaline and terlipressin (Drug)
step up terlipressin
Active Comparator
干预措施: step up terlipressin therapy (Drug)
结局指标
主要结局
the Response to treatment in each intervention group
时间窗: 2 years
次要结局
- Complications and the predictors of the treatment response(2 years)
- Side effects of the drug(3 months)
- Survival(15 days)
研究者
研究点 (1)
Loading locations...
相似试验
已完成
不适用
Acute Kidney Injury in Patients With Liver CirrhosisAcute Kidney Injury in Patients With Liver CirrhosisNCT06343389Sohag University180
进行中（未招募）
2 期
Endothelin Receptor Antagonism With Ambrisentan to Treat Hepatorenal SyndromeAscites HepaticAcute Kidney InjuryLiver CirrhosisHepatorenal SyndromeNCT06256432Noorik Biopharmaceuticals AG54
已完成
不适用
Risk of Acute Liver Failure Among Patients With Type 2 Diabetes Exposed to Oral Antidiabetic TreatmentsDiabetes Mellitus, Type 2NCT01086293AstraZeneca113,505
已完成
不适用
Prognostic Biomarkers For Acute Kidney Injury In Liver CirrhosisLiver CirrhosesBiomarkersAcute Kidney InjuryNCT03156426University of Edinburgh52
已完成
不适用
Infections in Hospitalized Cirrhotic PatientsCirrhosisNCT03137719Baylor Research Institute385