Study of Acute Kidney Injury in Patients With Liver Cirrhosis at Sohag University Hospital
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 180
- 试验地点
- 2
- 主要终点
- Incidence of acute kidney injury in cirrhotic patients in Sohag University Hospital
研究概览
简要总结
In our locality, limited studies have discussed AKI in patients with liver cirrhosis and its outcome, therefore we aim to highlight the incidence, patterns, risk factors, and outcomes of acute kidney injury in patients with liver cirrhosis at Sohag University Hospital.
详细描述
Acute kidney injury (AKI) is a common condition in patients with cirrhosis. It occurs in up to 50% of hospitalized patients with cirrhosis and in 58% of such patients in the intensive care unit. AKI is one of the key predictors for short-term mortality in patients with liver cirrhosis with mortality rates as high as 90%. There is a remarkable increase in length of hospital stay with high financial burden on patients with AKI.
In general, the three main causes of AKI are renal hypoperfusion (also referred to as prerenal AKI), which in most cases is due to hypovolemia; intrinsic, structural kidney injury; and postrenal injury due to urinary obstruction. A unique cause of AKI due to renal hypoperfusion in patients with cirrhosis is the hepatorenal syndrome (HRS), which is the result of renal vasoconstriction. Early identification and management of AKI may improve outcomes.
In our locality, limited studies have discussed AKI in patients with liver cirrhosis and its outcome, therefore we aim to highlight the incidence, patterns, risk factors, and outcomes of acute kidney injury in patients with liver cirrhosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Cirrhotic patients ( age more than 18 years old ) in Sohag University Hospital
排除标准
- •patients with known preexisting chronic kidney disease
- •patients who had undergone renal transplantation
- •malignancy
- •pregnancy
研究组 & 干预措施
group A
Cirrhotic patients with Acute kidney injury
干预措施: serum creatinine (Diagnostic Test)
group B
Cirrhotic patients without Acute kidney injury
干预措施: serum creatinine (Diagnostic Test)
结局指标
主要结局
Incidence of acute kidney injury in cirrhotic patients in Sohag University Hospital
时间窗: 1 year
Number of new cases of acute kidney injury (which will be diagnosed by either increase in serum creatinine ≥0.3 mg/dl within 48 hours; or, a percentage increase in serum creatinine ≥50% within the prior seven days) occurring in cirrhotic patients in Sohag University Hospital.
次要结局
未报告次要终点
研究者
Mohamed Shehab Ahmed
Sohag, Egypt
Sohag University