Ocular Penetration of Topical Tacrolimus Eye Drops
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Detection of the concentration of tacrolimus ( nanograms/milliliter) in the anterior chamber following ocular topical application.
研究概览
简要总结
Investigators aim to evaluate the ocular penetration of topical tacrolimus 0.03% eye drops.
Topical tacrolimus 0.03% will be instilled into the eyes of patients 15 minutes before cataract surgery. Aqueous samples will be collected at the time of cataract surgery and will be subjected to detection of presence and level of tacrolimus.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Any age or gender
- •Patients scheduled for routine cataract surgery
- •Clear healthy cornea
排除标准
- •Corneal pathology
- •Ocular surface disease
- •Intraocular inflammation
研究组 & 干预措施
Topical tacrolimus
Ten patients will be include. Topical tacrolimus 0.05% will be instilled into the eyes of patients 15 minutes before cataract surgery. Aqueous samples will be collected at the time of cataract surgery and will be subjected to detection of presence and level of tacrolimus.
干预措施: Tacrolimus (Drug)
结局指标
主要结局
Detection of the concentration of tacrolimus ( nanograms/milliliter) in the anterior chamber following ocular topical application.
时间窗: From date of obtaining the aqueous samples until getting the laboratory results of concentration of topical tacrolimus in the aqueous humor up to 2 months
次要结局
未报告次要终点
研究者
Samir S. Shoughy, MD, FRCS (Glasg.)
Principal Investigator
The Eye Center and The Eye Foundation for Research in Ophthalmology