Blood brain barrier permeability and inflammatory biomarkers in patients with depressio

Recruiting

• Conditions: F32.2; F32.3; F33.2; F33.3; Severe depressive episode without psychotic symptoms; Severe depressive episode with psychotic symptoms; Recurrent depressive disorder, current episode severe without psychotic symptoms; Recurrent depressive disorder, current episode severe with psychotic symptoms

• Registration Number: DRKS00022091
• Lead Sponsor: Klinik für Psychiatrie, Psychosomatik und PsychotherapieUniversitätsklinikum Frankfurt

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-07-06
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Patients:
- Presence of a severe single or recurrent depressive disorder with or without psychotic symptoms (according to ICD 10: F32.2, F32.3, F33.2, F33.3)
- ability to give consent

Healthy controls:
- Ability to give consent

Exclusion Criteria

Patients:
- Presence of a severe somatic or neurological disease
- Pregnancy and breastfeeding

Healthy controls:
- Presence of a psychiatric, severe somatic or neurological disease
- Pregnancy and breastfeeding

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
At the time of a high symptom load: cMRI, blood sampling (determination of various inflammation parameters, including interleukins, CRP), questionnaires (including QIDS, MADRS).<br>At the time of remission, but at the latest after 6 months, the same examinations are carried out.<br>In the healthy control subjects, the above-mentioned examinations are performed only once.

Secondary Outcome Measures

Name	Time	Method
Development of an individual inflammatory profile per participant and correlation of the same with imaging parameters