The effects of light on glucose metabolism

Completed

Conditions: glucose control
type 2 diabetes mellitus
10018424

Registration Number: NL-OMON46429

Lead Sponsor: niversiteit Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 26

Inclusion Criteria

* Male or female
* Caucasian
* Age 40-75 years
* BMI 25-35 kg/m2
* Stable weight (+/- 3 kg in the last 3 months)
* One of the four criteria for prediabetes:
- Impaired fasting glucose (6.1 mM to 6.9 mM)
- Blood glucose values 7.8-11.1 mM 2h after glucose drink consumption during OGTT in screening.
- Insulin Resistance: glucose clearance rate * 360 ml/kg/min, as determined using OGIS120.
- HbA1c of 5.7*6.4%.

Exclusion Criteria

* Fasting plasma glucose *7.0 mM
* Any medical condition and/or medication that might interfere with the investigated parameters as judged by study physician.
* Unstable body weight (+/- 3 kg in the last 3 months)
* Participants, who do not want to be informed about unexpected medical findings, or do not wish that their treating physician will be informed, cannot participate in this study.
* Blood donation one month prior to study and three months after finishing study.
* Participants with extreme chronotypes (going to bed extremely late/early).

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary endpoint is postprandial glucose measured every 30 minutes during 4<br /><br>hours.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>* Fasting glucose levels<br /><br>* Plasma metabolites (i.e. FFA, TGA, insulin)<br /><br>* 24 hour continuous glucose monitoring<br /><br>* 24 hour energy expenditure<br /><br>* Core body temperature and skin temperature<br /><br>* Subjective perception of thermal sensation and comfort, visual comfort,<br /><br>hunger and satiety, sleepiness</p><br>