Double blind placebo controlled trial of steroids in Bacterial Meningitis

Not Applicable

Completed

• Conditions: Bacterial meningitis; Nervous System Diseases

• Registration Number: ISRCTN42986828
• Lead Sponsor: niversity of Oxford (UK)

Brief Summary

2004 Results article in https://pubmed.ncbi.nlm.nih.gov/15496623 2007 Results article in https://pubmed.ncbi.nlm.nih.gov/18077808

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2000-01-01
• Study Start: 2005-07-22
• Last Update Posted: 7 November 2022

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

1. The treating physician believes the diagnosis to be BM
2. History less than ten days (unless still Serebrospinal Fluid [CSF] evidence of bacteria)
3. CSF white cell count more than 50 with more than 50% neutrophils
4. CSF glucose less than 50% of blood glucose

Exclusion Criteria

1. Chest X-Ray (CXR) shows evidence of possible Tuberculosis (TB)
2. History is longer than ten days
3. History of hypersensitivity to beta-lactam antibiotics
4. Known severe liver or renal impairment
5. Patients in whom the physician believes corticosteroids are contraindicated e.g. uncontrolled diabetes, gastro-intestinal bleeding etc.
6. Pre-existing severe neurological disability
7. Pregnancy within the first trimester

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mortality

Secondary Outcome Measures

Name	Time	Method
o secondary outcome measures