Sarcopenic Obesity: Estimation of Prevalence and Identification of Clinical and Biological Determinants in a Population of Adult Obese Patients
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 800
- 试验地点
- 2
- 主要终点
- Sarcopenia
研究概览
简要总结
This project aims first to determine the prevalence of sarcopenia in a population of obese people of extended age group (18-70 years). In a second step, the factors determining and / or predisposing to sarcopenic obesity will be identified as well as plasmatic and urinary biomarkers specific to this phenotype.
详细描述
Collection of clinical and paraclinical data (biological and anthropometric) for evaluation of sarcopenic obesity in obese patients.
Biological collection to identify plasma, serum, genetic, urinary and faecal biomarkers associated with sarcopenic obesity
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Screening
- 盲法
- None
盲法说明
No masking
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age: 18-70 years
- •Sex: men and women
- •Patient followed in clinical nutrition benefiting from a metabolic assessment for optimization of clinical and paraclinical management
- •Patient meeting the criteria of obesity defined by BMI> 30 kg / m²
- •Major patient with free, informed and signed consent
- •Patient covered by the social security scheme
排除标准
- •Patient with cancer or severe chronic disease (renal failure, respiratory failure, liver failure)
- •Patient with neuromuscular disease
- •Patient with a total inability to walk
- •Minor patient
- •Refusal of the patient to participate in the study
- •Pregnant or lactating women
- •Patient deprived of liberty or under guardianship.
研究组 & 干预措施
cohort
Collection of clinical and paraclinical data (biological and anthropometric) for evaluation of sarcopenic obesity in obese patients.
干预措施: collection (Other)
结局指标
主要结局
Sarcopenia
时间窗: at day 1
The primary endpoint is sarcopenia (present / absent), defined using the muscle mass index (SMI) corresponding to = SM / Height², where the total muscle mass (SM) is calculated from validated equations. by Janssen et al in a population of men and women with a large age range (18-86 years) and adiposity (BMI: 16-48 kg / m integrating bio-impedancemetry data ( BIA).
次要结局
未报告次要终点