Plant-based Dietary Protein and Resistance-training Adaptations

Not Applicable

Completed

• Conditions: Healthy

• Registration Number: NCT03907059
• Lead Sponsor: University of Sao Paulo

Brief Summary

Dietary protein consumption maximizes the anabolic response during resistance training (RT) by triggering muscle protein synthesis and providing the indispensable amino acids for a net positive protein balance. Leucine is considered the key amino acid in this process, suggesting that differences in protein quality may influence RT-induced gains in muscle mass and strength. In general, plant-based protein sources have lower leucine concentrations than animal-based protein sources and human skeletal muscle. In this respect, despite acute evidence on lower anabolic properties of plant- vs. animal-based protein, the effects of an exclusive plant-based dietary protein diet on RT-induced adaptations are currently unknown.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-03-31
• Primary Completion: 2018-10-16
• Study Completion: 2018-10-19
• Status Verified: 2019-04
• Study First Submitted: 2019-04-05
• Study First Submitted QC: 2019-04-05
• Last Update Submitted: 2019-04-05
• Study First Posted: 2019-04-08
• Last Update Posted: 2019-04-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 38

Inclusion Criteria

• Healthy young men
• Vegans ≥ 1 y or omnivorous subjects
• Physically active but no resistance-trained subjects
• Without any chronic injury that impairs resistance training performance
• Protein intake > 0.8 g/protein/kg body weight

Exclusion Criteria

• Use of creatine or beta-alanine supplements for the last 3 months
• Use of proteins and/or amino acids supplements for the last 1 month
• Engagement in specific dietary restrictions
• Previous use of anabolic steroids
• Engagement in any training program

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Muscle strength	12 weeks	assessed by leg-press one-maximum-repetition
Muscle cross-sectional area	12 weeks	assessed by mode-B ultrasound

Secondary Outcome Measures

Name	Time	Method
Leg lean mass	12 weeks	assessed by Dual-energy X-ray absorptiometry
fiber cross-sectional area	12 weeks	assessed by muscle biopsy (vastus lateralis)

Trial Locations

Locations (1)

University of Sao Paulo; 🇧🇷 Sao Paulo, SP, Brazil