Elimination of Protein-bound Uremic Retention Solutes by Prometheus Artificial Hepatic System Versus Conventional Dialysis
Not Applicable
Withdrawn
- Conditions
- Renal Failure, Chronic
- Registration Number
- NCT00262353
- Lead Sponsor
- University Hospital, Ghent
- Brief Summary
Comparison of the efficacy of dialysis by conventional dialysis versus Prometheus artificial hepatic system
- Detailed Description
After inclusion, patients will be dialysed with low-flux artificial kidneys. 1 week of dialysis exists of 3 days of dialysis. In week 4, day 2, patients will be treated once with the Prometheus artificial hepatic system or with high-flux dialysis. The other days low-flux kidneys will be used. Week 5 and 6 are a wash-out period. Week 7 is identical to week 4 but the other system than in week 4 is used. Blood samples are taken at regular moments in week 3, week 4 (day 2) and week 7 (day 2).
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- Stable patients
- At least 3 months on dialysis
- Arterio-venous fistula
Exclusion Criteria
- Diabetic patients
- Malignancies
- Acute illnesses
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Determination of the concentration of protein-bound toxins after treatment with different artificial devices
- Secondary Outcome Measures
Name Time Method Determination of the kinetics of protein-bound toxins after treatment with different artificial devices
Trial Locations
- Locations (1)
University Hospital Ghent
🇧🇪Ghent, Belgium