Increasing the Removal of Protein-Bound Solutes During Extended Hours Hemodialysis
Not Applicable
- Conditions
- End Stage Renal Failure on Dialysis
- Interventions
- Other: low dialysate flow, smaller dialyzerOther: high dialysate flow, larger dialyzer
- Registration Number
- NCT01892839
- Lead Sponsor
- Palo Alto Veterans Institute for Research
- Brief Summary
Hemodialysis keeps patients with renal failure alive but does not restore normal health. Retention of chemicals that bind to plasma proteins and are therefore poorly removed by dialysis may contribute to ill health in patients receiving conventional treatment. This proposal will test the effect of a new method designed to improve the removal of protein-bound solutes during dialysis. The effects on blood chemical levels of two different dialysis prescriptions will be tested in patients already undergoing nocturnal in-center hemodialysis three times weekly.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 24
Inclusion Criteria
- stable on nocturnal in-center dialysis located close to Stanford University and VA Palo Alto
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Exclusion Criteria
- recent use of antibiotics
- gastrointestinal disease
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description low dialysate flow, smaller dialyzer low dialysate flow, smaller dialyzer low dialysate flow, smaller dialyzer high dialysate flow, larger dialyzer high dialysate flow, larger dialyzer high dialysate flow, larger dialyzer
- Primary Outcome Measures
Name Time Method Plasma levels of the chemical p-cresol sulfate Participants will be followed for 2-3 weeks on different dialysis prescriptions and plasma chemical levels will be measured at the end of this period.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (2)
Satellite Redwood City
🇺🇸Redwood City, California, United States
Stanford University
🇺🇸Stanford, California, United States