A Pilot Study of the Effects of Replacing Orange Carrots and White Potatoes With Purple Varieties, on Risk Factors for Cardiovascular Disease
试验速览
- 阶段
- 1 期
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Blood cholesterol
研究概览
简要总结
The hypothesis is that richly coloured purple vegetables, rich in polyphenolic compounds including anthocyanins will have higher antioxidant and other biological activities, than more lightly coloured versions of these foods. Diets of human subjects will be modified to allow consumption of 200-300 g of raw carrots or cooked potatoes. Participants will be randomized to consume either orange or purple carrots, or white or purple potatoes. They will consume these diets for 12 weeks and bioavailability of polyphenolics will be examined as well as anthropometry and blood biochemistry for changes in risk factors associated with cardiovascular disease.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •adult men and women 18-65 years of age
- •must have a least one of the following risk factors associated with increased risk of type II diabetes and/or cardiovascular disease:
- •borderline high or hypertension or undergoing treatment for such
- •abnormal fasting blood glucose or undergoing treatment for such
- •overweight or obese
- •borderline high or high LDL-cholesterol or undergoing treatment for such
- •borderline low or low HDL-cholesterol
- •borderline high or high triglycerides or undergoing treatment for such
排除标准
- •smokers, pregnant or nursing women
结局指标
主要结局
Blood cholesterol
时间窗: 12 weeks
blood will be collected at baseline before the experimental foods are introduced and again 6 weeks into the intervention period and during the last week of the intervention (week 12)
次要结局
- blood pressure(12 weeks)
- body composition(12 weeks)
- insulin resistance(12 weeks)
- blood and urinary polyphenol metabolites(12 weeks)
- circulating biomarkers of cardiovascular disease and type II diabetes risk(12 weeks)
研究者
Kelly Anne Meckling, PhD
Professor
University of Guelph