A study examining the effect of blood and plasma donation on serum per- and poly-fluoroalkyl substances (PFAS) levels in Metropolitan Fire Brigade staff

Not Applicable

Completed

• Conditions: per- and poly-fluoroalkyl substances (PFAS) contamination; Public Health - Other public health

• Registration Number: ACTRN12619000204145
• Lead Sponsor: Macquarie University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-02-12
• Study Completion: 2021-03-26
• Last Update Posted: 27 June 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 285

Inclusion Criteria

1. Metropolitan Fire Brigade staff with 10 or more years of previous occupational exposure to PFAS.

2. PFOS levels >=5ng/mL

3. Eligible to donate blood (in accordance with the ARCBS guidelines).

4. Not donated blood in the past 3 months.

5. Signed and dated informed consent document indicating that the participant has been informed of all pertinent aspects of the trial prior to enrolment.

6. Willingness and ability to comply with scheduled visits, laboratory tests and other study procedures.

Exclusion Criteria

1. Medical contraindication to blood donation.

2. Other severe acute or chronic medical or psychiatric condition, or laboratory abnormality that may increase the risk associated with study participation or study drug administration or may interfere with the interpretation of study results, and in the judgment of the investigator would make the participant inappropriate for entry into this study.

3. Previous ineligibility to donate blood.

4. Planned travel or extended leave (e.g. >6 weeks) that would prevent access to blood donation facilities.

Study & Design

• Study Type: Interventional
• Study Design: Not specified