Pressure support ventilation and NAVA during noninvasive ventilation in acute respiratory failure: a pilot study

Completed

• Conditions: acute respiratory failure; Dyspnea; 10028393; 10038716

• Registration Number: NL-OMON36788
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 12

Inclusion Criteria

* Acute respiratory failure requiring noninvasive ventilatory support in ICU.
* COPD (past medical history)
* Able to adequately oxygenate and ventilate without support for ± 5 minutes (necessary for changing the interface).
* Age > 18 years
* Mentally competent

Exclusion Criteria

* Severe hypoxemic failure (Pa,o2 < 8.0 kPa with nonrebreathing mask) at time of inclusion
* Planned endotracheal intubation
* Hemodynamic instability requiring high dose vasopressors (>0.5 ug/kg/min)
* Contraindication for insertion of nasogastric tube (recent esophageal, facial or cranial trauma or surgery. espohageal varices, recent (< 4 weeks) upper gastrointestinal bleeding)
* Severe agitation
* Myopathy before ICU admission (including Steinert disease, Duchenne muscular dystrophy)
* Severely decreased consciousness (GCS < 11)
* Tracheostomy
* Inability to obtain informed consent.
* Nasogastric tube in situ

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>* Patient - ventilator asynchrony index</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>* Dyspnea score (VAS)<br /><br><br /><br>* Arterial carbondioxe and oxygen tension after each change in protocol (0, 30,<br /><br>60, 90, 125, 155 and 185 minutes)<br /><br><br /><br>* Oxygenation index<br /><br><br /><br>* Airleak during NIV<br /><br><br /><br>* Ventilator efficiency (airway pressure / diaphragm electrical activity)</p><br>