Pressure Support Ventilation (PSV) or Synchronised Intermittent Mandatory Ventilation (SIMV) for weaning preterm infants on mechanical ventilatio
Completed
- Conditions
- Respiratory distress syndrome in preterm babiesRespiratoryRespiratory distress syndrome
- Registration Number
- ISRCTN74272142
- Lead Sponsor
- orth Tees and Hartlepool NHS Foundation Trust (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 110
Inclusion Criteria
1. Preterm infants with RDS, stratified into three groups (23+0 to 25+6, 26+0 to 28+6 and 29+0 to 31+6 weeks) based on their gestation at birth would be enrolled if they are needing mechanical ventilation through an endotracheal tube for at least 6 hours
2. Signed parental consent is obtained before randomisation
Exclusion Criteria
1. Severe congenital malformation
2. Neuromuscular disorder demonstrated clinically with decreased muscular tone
3. Upper airway anomaly
4. Infants transferred from other unit who have met the study entry criteria on admission to the neonatal unit
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary endpoint is duration of weaning on mechanical ventilation - defined as time from commencing weaning in the assigned mode of respiratory support to the time when the infant is ready for extuabtion demonstrated by passing the MVT
- Secondary Outcome Measures
Name Time Method 1. Total duration of mechanical support through the endotracheal (ET) tube<br>2. Total duration of respiratory support including non invasive respiratory support <br>3. Discharge on home oxygen<br>4. Complications of prematurity